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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Smyd1SET and MYND domain containing 1. (45 aa)    
Predicted Functional Partners:
Tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
   
 0.915
Dot1l
Histone-lysine N-methyltransferase, H3 lysine-79 specific.
    
 0.836
Kmt2e
Histone-lysine N-methyltransferase 2E isoform X1.
    
 0.829
Ash2l
set1/Ash2 histone methyltransferase complex subunit ASH2.
    
 0.785
Rbbp5
Retinoblastoma-binding protein 5.
    
 0.774
Setd2
Histone-lysine N-methyltransferase SETD2.
     
 0.766
Setd1a
Histone-lysine N-methyltransferase SETD1A isoform X1.
    
 0.764
Setd1b
Histone-lysine N-methyltransferase SETD1B.
    
 0.764
Suz12
Polycomb protein SUZ12.
    
 0.761
Setd7
SET domain containing 7, histone lysine methyltransferase.
   
 
 0.753
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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