E2f1 protein (Mesocricetus auratus) - STRING interaction network

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Score

E2f1

Transcription factor E2F1. (383 aa)

Predicted Functional Partners:

Rb1

0.999

Tfdp1

0.996

Ccna2

0.987

Tfdp2

0.984

Rbl1

0.980

Ccna1

0.974

Cdk2

0.974

Rbl2

0.953

E2f2

0.943

Brd4

0.943

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Brd4	E2f1	ENSMAUP00000021259	ENSMAUP00000001222	Bromodomain-containing protein 4 isoform X1.	Transcription factor E2F1.	0.943
Brd4	E2f2	ENSMAUP00000021259	ENSMAUP00000003742	Bromodomain-containing protein 4 isoform X1.	Transcription factor E2F2 isoform X1.	0.508
Brd4	Rb1	ENSMAUP00000021259	ENSMAUP00000023832	Bromodomain-containing protein 4 isoform X1.	Retinoblastoma-associated protein.	0.404
Ccna1	Ccna2	ENSMAUP00000012847	ENSMAUP00000020143	cyclin-A1; Belongs to the cyclin family.	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	0.922
Ccna1	Cdk2	ENSMAUP00000012847	ENSMAUP00000021672	cyclin-A1; Belongs to the cyclin family.	Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...]	0.997
Ccna1	E2f1	ENSMAUP00000012847	ENSMAUP00000001222	cyclin-A1; Belongs to the cyclin family.	Transcription factor E2F1.	0.974
Ccna1	E2f2	ENSMAUP00000012847	ENSMAUP00000003742	cyclin-A1; Belongs to the cyclin family.	Transcription factor E2F2 isoform X1.	0.932
Ccna1	Rb1	ENSMAUP00000012847	ENSMAUP00000023832	cyclin-A1; Belongs to the cyclin family.	Retinoblastoma-associated protein.	0.973
Ccna1	Rbl1	ENSMAUP00000012847	ENSMAUP00000003710	cyclin-A1; Belongs to the cyclin family.	Retinoblastoma-like protein 1 isoform X1.	0.835
Ccna1	Rbl2	ENSMAUP00000012847	ENSMAUP00000015114	cyclin-A1; Belongs to the cyclin family.	Retinoblastoma-like protein 2 isoform X2.	0.835
Ccna1	Tfdp1	ENSMAUP00000012847	ENSMAUP00000009243	cyclin-A1; Belongs to the cyclin family.	Transcription factor.	0.717
Ccna1	Tfdp2	ENSMAUP00000012847	ENSMAUP00000018056	cyclin-A1; Belongs to the cyclin family.	Transcription factor.	0.712
Ccna2	Ccna1	ENSMAUP00000020143	ENSMAUP00000012847	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	cyclin-A1; Belongs to the cyclin family.	0.922
Ccna2	Cdk2	ENSMAUP00000020143	ENSMAUP00000021672	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...]	0.999
Ccna2	E2f1	ENSMAUP00000020143	ENSMAUP00000001222	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	Transcription factor E2F1.	0.987
Ccna2	E2f2	ENSMAUP00000020143	ENSMAUP00000003742	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	Transcription factor E2F2 isoform X1.	0.934
Ccna2	Rb1	ENSMAUP00000020143	ENSMAUP00000023832	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	Retinoblastoma-associated protein.	0.989
Ccna2	Rbl1	ENSMAUP00000020143	ENSMAUP00000003710	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	Retinoblastoma-like protein 1 isoform X1.	0.950
Ccna2	Rbl2	ENSMAUP00000020143	ENSMAUP00000015114	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	Retinoblastoma-like protein 2 isoform X2.	0.925
Ccna2	Tfdp1	ENSMAUP00000020143	ENSMAUP00000009243	Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.	Transcription factor.	0.718

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