Clu protein (Mesocricetus auratus) - STRING interaction network

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Clu

Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (448 aa)

Predicted Functional Partners:

App

0.949

Ltf

0.878

Xrcc6

0.833

Pon1

0.805

Apoe

0.797

Aplp2

0.793

Apoa4

0.761

Vldlr

0.760

Lrp2

0.750

Apoc1

0.745

Your Current Organism:

Mesocricetus auratus

NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Aplp2	Apoe	ENSMAUP00000013226	ENSMAUP00000016807	Amyloid-like protein 2 isoform X1.	Apolipoprotein E.	0.781
Aplp2	App	ENSMAUP00000013226	ENSMAUP00000002478	Amyloid-like protein 2 isoform X1.	Amyloid beta A4 protein.	0.714
Aplp2	Clu	ENSMAUP00000013226	ENSMAUP00000001386	Amyloid-like protein 2 isoform X1.	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	0.793
Aplp2	Lrp2	ENSMAUP00000013226	ENSMAUP00000006115	Amyloid-like protein 2 isoform X1.	Low-density lipoprotein receptor-related protein 2.	0.505
Aplp2	Vldlr	ENSMAUP00000013226	ENSMAUP00000000903	Amyloid-like protein 2 isoform X1.	Very low-density lipoprotein receptor isoform X1.	0.405
Apoa4	Apoc1	ENSMAUP00000020604	ENSMAUP00000023284	Apolipoprotein A-IV.	Apolipoprotein C-I.	0.823
Apoa4	Apoe	ENSMAUP00000020604	ENSMAUP00000016807	Apolipoprotein A-IV.	Apolipoprotein E.	0.927
Apoa4	Clu	ENSMAUP00000020604	ENSMAUP00000001386	Apolipoprotein A-IV.	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	0.761
Apoa4	Pon1	ENSMAUP00000020604	ENSMAUP00000017732	Apolipoprotein A-IV.	Serum paraoxonase/arylesterase 1.	0.621
Apoa4	Vldlr	ENSMAUP00000020604	ENSMAUP00000000903	Apolipoprotein A-IV.	Very low-density lipoprotein receptor isoform X1.	0.589
Apoc1	Apoa4	ENSMAUP00000023284	ENSMAUP00000020604	Apolipoprotein C-I.	Apolipoprotein A-IV.	0.823
Apoc1	Apoe	ENSMAUP00000023284	ENSMAUP00000016807	Apolipoprotein C-I.	Apolipoprotein E.	0.958
Apoc1	Clu	ENSMAUP00000023284	ENSMAUP00000001386	Apolipoprotein C-I.	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	0.745
Apoc1	Pon1	ENSMAUP00000023284	ENSMAUP00000017732	Apolipoprotein C-I.	Serum paraoxonase/arylesterase 1.	0.687
Apoc1	Vldlr	ENSMAUP00000023284	ENSMAUP00000000903	Apolipoprotein C-I.	Very low-density lipoprotein receptor isoform X1.	0.785
Apoe	Aplp2	ENSMAUP00000016807	ENSMAUP00000013226	Apolipoprotein E.	Amyloid-like protein 2 isoform X1.	0.781
Apoe	Apoa4	ENSMAUP00000016807	ENSMAUP00000020604	Apolipoprotein E.	Apolipoprotein A-IV.	0.927
Apoe	Apoc1	ENSMAUP00000016807	ENSMAUP00000023284	Apolipoprotein E.	Apolipoprotein C-I.	0.958
Apoe	App	ENSMAUP00000016807	ENSMAUP00000002478	Apolipoprotein E.	Amyloid beta A4 protein.	0.954
Apoe	Clu	ENSMAUP00000016807	ENSMAUP00000001386	Apolipoprotein E.	Clusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...]	0.797

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