Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Csnk1a1Casein kinase I isoform X3; Belongs to the protein kinase superfamily. (336 aa)    
Predicted Functional Partners:
Ctnnb1
Catenin beta-1.
   
 0.999
Axin1
Axin-1 isoform X1.
    
 0.999
Apc
Adenomatous polyposis coli protein isoform X4.
    
 0.999
Axin2
Axin-2.
    
 0.997
Gsk3b
Glycogen synthase kinase-3 beta; Belongs to the protein kinase superfamily.
    
 0.996
Smo
Smoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family.
    
 0.994
Apc2
Adenomatous polyposis coli protein 2 isoform X3.
    
 0.991
Grk3
G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.
     
 0.971
Grk2
Beta-adrenergic receptor kinase 1; Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation- independent manner. Positively regulates ciliary smoothened (SMO)- dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity. Belongs to the protei [...]
     
 0.971
Crbn
Protein cereblon isoform X2.
    
 
 0.967
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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