node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Crlf1 | Gh1 | ENSMAUP00000024092 | ENSMAUP00000003112 | Cytokine receptor-like factor 1 isoform X2. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.915 |
Crlf1 | Ghr | ENSMAUP00000024092 | ENSMAUP00000001155 | Cytokine receptor-like factor 1 isoform X2. | Growth hormone receptor. | 0.812 |
Crlf1 | Il6 | ENSMAUP00000024092 | ENSMAUP00000019183 | Cytokine receptor-like factor 1 isoform X2. | Interleukin-6. | 0.780 |
Crlf1 | Jak2 | ENSMAUP00000024092 | ENSMAUP00000006704 | Cytokine receptor-like factor 1 isoform X2. | Tyrosine-protein kinase. | 0.571 |
Crlf1 | Jak3 | ENSMAUP00000024092 | ENSMAUP00000009122 | Cytokine receptor-like factor 1 isoform X2. | Tyrosine-protein kinase. | 0.571 |
Crlf1 | Lep | ENSMAUP00000024092 | ENSMAUP00000023875 | Cytokine receptor-like factor 1 isoform X2. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.801 |
Crlf1 | Prl2b1 | ENSMAUP00000024092 | ENSMAUP00000001408 | Cytokine receptor-like factor 1 isoform X2. | prolactin-2B1-like. | 0.723 |
Egfr | Gh1 | ENSMAUP00000000794 | ENSMAUP00000003112 | Receptor protein-tyrosine kinase. | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | 0.849 |
Egfr | Il6 | ENSMAUP00000000794 | ENSMAUP00000019183 | Receptor protein-tyrosine kinase. | Interleukin-6. | 0.938 |
Egfr | Jak2 | ENSMAUP00000000794 | ENSMAUP00000006704 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.945 |
Egfr | Jak3 | ENSMAUP00000000794 | ENSMAUP00000009122 | Receptor protein-tyrosine kinase. | Tyrosine-protein kinase. | 0.909 |
Egfr | Lep | ENSMAUP00000000794 | ENSMAUP00000023875 | Receptor protein-tyrosine kinase. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.912 |
Egfr | Prl2b1 | ENSMAUP00000000794 | ENSMAUP00000001408 | Receptor protein-tyrosine kinase. | prolactin-2B1-like. | 0.504 |
Gh1 | Crlf1 | ENSMAUP00000003112 | ENSMAUP00000024092 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Cytokine receptor-like factor 1 isoform X2. | 0.915 |
Gh1 | Egfr | ENSMAUP00000003112 | ENSMAUP00000000794 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Receptor protein-tyrosine kinase. | 0.849 |
Gh1 | Ghr | ENSMAUP00000003112 | ENSMAUP00000001155 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Growth hormone receptor. | 0.982 |
Gh1 | Il6 | ENSMAUP00000003112 | ENSMAUP00000019183 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Interleukin-6. | 0.689 |
Gh1 | Jak2 | ENSMAUP00000003112 | ENSMAUP00000006704 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Tyrosine-protein kinase. | 0.852 |
Gh1 | Jak3 | ENSMAUP00000003112 | ENSMAUP00000009122 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Tyrosine-protein kinase. | 0.852 |
Gh1 | Lep | ENSMAUP00000003112 | ENSMAUP00000023875 | Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.869 |