Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Ctnnb1Catenin beta-1. (781 aa)    
Predicted Functional Partners:
Egfr
Receptor protein-tyrosine kinase.
    
 0.999
Csnk1a1
Casein kinase I isoform X3; Belongs to the protein kinase superfamily.
   
 0.999
Ruvbl1
RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.
   
 0.999
Siah1
E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.
    
 0.999
Fbxw11
F-box/WD repeat-containing protein 11 isoform X1.
    
 0.999
Psen1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
    
 0.999
Ep300
Histone acetyltransferase p300 isoform X3.
    
 0.999
Cdh3
Cadherin-3; Cadherins are calcium-dependent cell adhesion proteins.
   
 0.999
Lef1
Lymphoid enhancer-binding factor 1 isoform X2.
    
 0.999
Axin2
Axin-2.
    
 0.999
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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