close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ppp1r13bApoptosis-stimulating of p53 protein 1 isoform X2. (1035 aa)    
Predicted Functional Partners:
Tp53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]
    
 0.968
Hif1an
Hypoxia-inducible factor 1-alpha inhibitor.
    
   0.900
Ppp1cb
Protein phosphatase 1 catalytic subunit beta.
    
 0.898
Il10
Interleukin-10 isoform X1.
    
 0.877
Ppp1cc
Protein phosphatase 1 catalytic subunit gamma.
    
 0.873
Ppp1ca
Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family.
    
 0.873
Il22
Interleukin-22.
    
 0.872
Wwtr1
WW domain-containing transcription regulator protein 1 isoform X2.
    
 0.867
Il10ra
Interleukin-10 receptor subunit alpha isoform X2.
   
 0.861
Il22ra1
Interleukin-22 receptor subunit alpha-1.
    
 0.853
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.