close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cdkn2dCyclin-dependent kinase 4 inhibitor D. (166 aa)    
Predicted Functional Partners:
Cdk6
Cyclin-dependent kinase 6.
    
 0.999
Cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
 0.994
Ccnd2
G1/S-specific cyclin-D2; Belongs to the cyclin family.
    
 0.933
Ccnd3
G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.
    
 0.913
Cdk2
Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...]
    
 0.910
Ccnd1
G1/S-specific cyclin-D1; Belongs to the cyclin family.
    
 0.887
Cdk3
Cyclin-dependent kinase 3 isoform X2; Belongs to the protein kinase superfamily.
    
 0.885
Cdk1
Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily.
    
 0.868
Cdk14
Cyclin-dependent kinase 14; Belongs to the protein kinase superfamily.
    
 0.758
Cdk18
Cyclin-dependent kinase 18; Belongs to the protein kinase superfamily.
    
 0.758
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.