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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IdeInsulin-degrading enzyme isoform X1; Belongs to the peptidase M16 family. (1020 aa)    
Predicted Functional Partners:
Ins
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
    
 0.992
App
Amyloid beta A4 protein.
    
 
 0.974
Iapp
Islet amyloid polypeptide; Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism; Belongs to the calcitonin family.
    
 
 0.967
Igf2
Insulin-like growth factor II isoform X1.
    
 
 0.944
Rps27a
ubiquitin-40S ribosomal protein S27a.
    
  0.920
ENSMAUP00000019431
annotation not available
    
  0.920
Nppa
Natriuretic peptides A.
    
 
 0.906
Tgfa
Protransforming growth factor alpha.
    
 
 0.901
Nppb
Natriuretic peptides B.
    
 
 0.901
Fap
Prolyl endopeptidase FAP; Belongs to the peptidase S9B family.
    
 
 0.894
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.