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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Alx4Homeobox protein aristaless-like 4. (399 aa)    
Predicted Functional Partners:
Ldb1
LIM domain-binding protein 1 isoform X1.
    
 0.671
Ldb2
LIM domain-binding protein 2 isoform X1.
    
 0.671
Srf
Serum response factor isoform X1.
    
 0.599
Tcf4
Transcription factor 4.
    
  0.582
Tcf3
Transcription factor E2-alpha; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (By similarity).
    
  0.582
Ext2
Exostosin-2; Belongs to the glycosyltransferase 47 family.
      
 0.570
Gli3
Transcriptional activator GLI3.
  
 
 
 0.532
Cbfb
Core-binding factor subunit beta isoform X2.
    
  0.488
Lhx4
LIM/homeobox protein Lhx4.
    
0.473
Lhx3
LIM/homeobox protein Lhx3 isoform X1.
    
0.473
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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