| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Ep300 | Esr1 | ENSMAUP00000003797 | ENSMAUP00000005000 | Histone acetyltransferase p300 isoform X3. | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | 0.989 |
| Ep300 | Esr2 | ENSMAUP00000003797 | ENSMAUP00000021595 | Histone acetyltransferase p300 isoform X3. | Estrogen receptor beta. | 0.930 |
| Ep300 | Med1 | ENSMAUP00000003797 | ENSMAUP00000020235 | Histone acetyltransferase p300 isoform X3. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.778 |
| Ep300 | Ncoa1 | ENSMAUP00000003797 | ENSMAUP00000018092 | Histone acetyltransferase p300 isoform X3. | Nuclear receptor coactivator. | 0.981 |
| Ep300 | Ncoa2 | ENSMAUP00000003797 | ENSMAUP00000019130 | Histone acetyltransferase p300 isoform X3. | Nuclear receptor coactivator. | 0.974 |
| Ep300 | Ncoa3 | ENSMAUP00000003797 | ENSMAUP00000009481 | Histone acetyltransferase p300 isoform X3. | Nuclear receptor coactivator. | 0.990 |
| Ep300 | Ncor1 | ENSMAUP00000003797 | ENSMAUP00000022218 | Histone acetyltransferase p300 isoform X3. | Nuclear receptor corepressor 1. | 0.899 |
| Ep300 | Pgr | ENSMAUP00000003797 | ENSMAUP00000021389 | Histone acetyltransferase p300 isoform X3. | Progesterone receptor. | 0.770 |
| Ep300 | Sp1 | ENSMAUP00000003797 | ENSMAUP00000020396 | Histone acetyltransferase p300 isoform X3. | Transcription factor Sp1 isoform X1. | 0.995 |
| Ep300 | Src | ENSMAUP00000003797 | ENSMAUP00000008547 | Histone acetyltransferase p300 isoform X3. | Tyrosine-protein kinase. | 0.486 |
| Esr1 | Ep300 | ENSMAUP00000005000 | ENSMAUP00000003797 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Histone acetyltransferase p300 isoform X3. | 0.989 |
| Esr1 | Esr2 | ENSMAUP00000005000 | ENSMAUP00000021595 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Estrogen receptor beta. | 0.988 |
| Esr1 | Med1 | ENSMAUP00000005000 | ENSMAUP00000020235 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.983 |
| Esr1 | Ncoa1 | ENSMAUP00000005000 | ENSMAUP00000018092 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.999 |
| Esr1 | Ncoa2 | ENSMAUP00000005000 | ENSMAUP00000019130 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.998 |
| Esr1 | Ncoa3 | ENSMAUP00000005000 | ENSMAUP00000009481 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor coactivator. | 0.997 |
| Esr1 | Ncor1 | ENSMAUP00000005000 | ENSMAUP00000022218 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Nuclear receptor corepressor 1. | 0.975 |
| Esr1 | Pgr | ENSMAUP00000005000 | ENSMAUP00000021389 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Progesterone receptor. | 0.975 |
| Esr1 | Sp1 | ENSMAUP00000005000 | ENSMAUP00000020396 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Transcription factor Sp1 isoform X1. | 0.992 |
| Esr1 | Src | ENSMAUP00000005000 | ENSMAUP00000008547 | Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] | Tyrosine-protein kinase. | 0.991 |
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