STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Zic3Zinc finger protein ZIC 3. (466 aa)    
Predicted Functional Partners:
Acvr2b
Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    
 0.633
Abca1
ATP-binding cassette sub-family A member 1 isoform X2.
    
 
 0.632
Sufu
Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...]
    
  0.612
Gtf3c3
General transcription factor 3C polypeptide 3.
    
 0.603
App
Amyloid beta A4 protein.
      
 0.600
Sox2
Transcription factor SOX-2.
   
 0.549
Svep1
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 isoform X1.
    
 0.537
Lamtor2
Ragulator complex protein LAMTOR2 isoform X1.
    
  0.531
Ripk4
Receptor-interacting serine/threonine-protein kinase 4.
    
 0.531
Pou5f1
POU domain protein.
    
 0.530
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.