STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Pwwp2aPWWP domain-containing protein 2A isoform X1. (653 aa)    
Predicted Functional Partners:
Wrn
Werner syndrome ATP-dependent helicase isoform X1.
   
 0.996
Atr
Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.
   
 0.993
Nbn
Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
    
 0.992
Mre11
Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.
   
 0.989
Rad50
DNA repair protein RAD50.
   
 0.981
Nbr1
Next to BRCA1 gene 1 protein.
     
 0.975
Chek2
Serine/threonine-protein kinase Chk2.
    
 0.973
Tp53bp1
TP53-binding protein 1 isoform X2.
    
 0.970
Paxip1
PAX-interacting protein 1 isoform X1.
   
 0.967
Bard1
BRCA1-associated RING domain protein 1 isoform X1.
    
 0.951
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.