STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tnfsf4Tumor necrosis factor ligand superfamily member 4; Belongs to the tumor necrosis factor family. (192 aa)    
Predicted Functional Partners:
Tnfrsf4
Tumor necrosis factor receptor superfamily member 4 isoform X2.
    
 0.997
Tnfsf9
Tumor necrosis factor ligand superfamily member 9 isoform X2; Belongs to the tumor necrosis factor family.
  
   
 0.651
Il4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]
  
   
 0.635
Tnfrsf9
Tumor necrosis factor receptor superfamily member 9 isoform X2.
   
  
 0.615
Icos
Inducible T-cell costimulator.
   
  
 0.601
Cd27
CD27 antigen.
      
 0.600
Cd40lg
CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.
      
 0.595
Tnfrsf8
Tumor necrosis factor receptor superfamily member 8 isoform X2.
      
 0.562
Tnfsf18
Tumor necrosis factor ligand superfamily member 18; Belongs to the tumor necrosis factor family.
      
 0.544
Cd28
T-cell-specific surface glycoprotein CD28.
      
 0.539
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.