node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Hmgcr | Insig1 | ENSMAUP00000011794 | ENSMAUP00000001089 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | 0.937 |
Hmgcr | Npc1 | ENSMAUP00000011794 | ENSMAUP00000010400 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | Niemann-Pick C1 protein. | 0.472 |
Hmgcr | Npc1l1 | ENSMAUP00000011794 | ENSMAUP00000014807 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | Niemann-Pick C1-like protein 1 precursor. | 0.640 |
Hmgcr | Scap | ENSMAUP00000011794 | ENSMAUP00000023455 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | Sterol regulatory element-binding protein cleavage-activating protein. | 0.587 |
Hmgcr | Srebf1 | ENSMAUP00000011794 | ENSMAUP00000017031 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | Sterol regulatory element-binding protein 1 isoform X1. | 0.733 |
Hmgcr | Srebf2 | ENSMAUP00000011794 | ENSMAUP00000015158 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | Sterol regulatory element-binding protein 2. | 0.853 |
Insig1 | Hmgcr | ENSMAUP00000001089 | ENSMAUP00000011794 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | 0.937 |
Insig1 | Npc1 | ENSMAUP00000001089 | ENSMAUP00000010400 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | Niemann-Pick C1 protein. | 0.743 |
Insig1 | Npc1l1 | ENSMAUP00000001089 | ENSMAUP00000014807 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | Niemann-Pick C1-like protein 1 precursor. | 0.767 |
Insig1 | Scap | ENSMAUP00000001089 | ENSMAUP00000023455 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | Sterol regulatory element-binding protein cleavage-activating protein. | 0.954 |
Insig1 | Srebf1 | ENSMAUP00000001089 | ENSMAUP00000017031 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | Sterol regulatory element-binding protein 1 isoform X1. | 0.766 |
Insig1 | Srebf2 | ENSMAUP00000001089 | ENSMAUP00000015158 | Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. | Sterol regulatory element-binding protein 2. | 0.789 |
Kpnb1 | Srebf1 | ENSMAUP00000004678 | ENSMAUP00000017031 | Importin subunit beta-1. | Sterol regulatory element-binding protein 1 isoform X1. | 0.893 |
Kpnb1 | Srebf2 | ENSMAUP00000004678 | ENSMAUP00000015158 | Importin subunit beta-1. | Sterol regulatory element-binding protein 2. | 0.971 |
Mbtps2 | Scap | ENSMAUP00000018595 | ENSMAUP00000023455 | Membrane-bound transcription factor site-2 protease isoform X1. | Sterol regulatory element-binding protein cleavage-activating protein. | 0.574 |
Mbtps2 | Srebf1 | ENSMAUP00000018595 | ENSMAUP00000017031 | Membrane-bound transcription factor site-2 protease isoform X1. | Sterol regulatory element-binding protein 1 isoform X1. | 0.811 |
Mbtps2 | Srebf2 | ENSMAUP00000018595 | ENSMAUP00000015158 | Membrane-bound transcription factor site-2 protease isoform X1. | Sterol regulatory element-binding protein 2. | 0.811 |
Med15 | Srebf1 | ENSMAUP00000022256 | ENSMAUP00000017031 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Sterol regulatory element-binding protein 1 isoform X1. | 0.827 |
Med15 | Srebf2 | ENSMAUP00000022256 | ENSMAUP00000015158 | Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Sterol regulatory element-binding protein 2. | 0.796 |
Npc1 | Hmgcr | ENSMAUP00000010400 | ENSMAUP00000011794 | Niemann-Pick C1 protein. | 3-hydroxy-3-methylglutaryl-coenzyme A reductase; Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins; Belongs to the HMG-CoA reductase family. | 0.472 |