STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC101832771Keratin, type II cuticular Hb1 isoform X1; Belongs to the intermediate filament family. (479 aa)    
Predicted Functional Partners:
Ppp2r2b
Protein phosphatase 2, regulatory subunit B, beta.
    
 0.641
Ppp2r2a
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.
    
 0.641
Egfr
Receptor protein-tyrosine kinase.
    
 0.628
LOC101830046
Receptor protein-tyrosine kinase.
    
 0.628
Erbb2
Receptor tyrosine-protein kinase erbB-2; Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and [...]
    
 0.628
Erbb4
Receptor protein-tyrosine kinase.
    
 0.628
Ripk4
Receptor-interacting serine/threonine-protein kinase 4.
    
 0.601
Espl1
Separin.
    
 0.589
Bard1
BRCA1-associated RING domain protein 1 isoform X1.
    
 0.587
Plk4
Serine/threonine-protein kinase PLK4 isoform X1.
    
 0.585
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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