node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bckdha | Fdft1 | ENSMAUP00000015833 | ENSMAUP00000022823 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Squalene synthase. | 0.574 |
Bckdha | Ndufaf6 | ENSMAUP00000015833 | ENSMAUP00000017741 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6. | 0.574 |
Bckdha | Pyroxd2 | ENSMAUP00000015833 | ENSMAUP00000019555 | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2. | 0.852 |
Coq2 | Fdft1 | ENSMAUP00000013272 | ENSMAUP00000022823 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Squalene synthase. | 0.776 |
Coq2 | Kmo | ENSMAUP00000013272 | ENSMAUP00000000569 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.824 |
Coq2 | Ndufaf6 | ENSMAUP00000013272 | ENSMAUP00000017741 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6. | 0.774 |
Coq2 | Pyroxd2 | ENSMAUP00000013272 | ENSMAUP00000019555 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2. | 0.788 |
Coq2-2 | Fdft1 | ENSMAUP00000013903 | ENSMAUP00000022823 | Coenzyme Q2, polyprenyltransferase. | Squalene synthase. | 0.776 |
Coq2-2 | Kmo | ENSMAUP00000013903 | ENSMAUP00000000569 | Coenzyme Q2, polyprenyltransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.824 |
Coq2-2 | Ndufaf6 | ENSMAUP00000013903 | ENSMAUP00000017741 | Coenzyme Q2, polyprenyltransferase. | NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6. | 0.774 |
Coq2-2 | Pyroxd2 | ENSMAUP00000013903 | ENSMAUP00000019555 | Coenzyme Q2, polyprenyltransferase. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2. | 0.788 |
Fdft1 | Bckdha | ENSMAUP00000022823 | ENSMAUP00000015833 | Squalene synthase. | 2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.574 |
Fdft1 | Coq2 | ENSMAUP00000022823 | ENSMAUP00000013272 | Squalene synthase. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.776 |
Fdft1 | Coq2-2 | ENSMAUP00000022823 | ENSMAUP00000013903 | Squalene synthase. | Coenzyme Q2, polyprenyltransferase. | 0.776 |
Fdft1 | Kmo | ENSMAUP00000022823 | ENSMAUP00000000569 | Squalene synthase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.910 |
Fdft1 | Ndufaf6 | ENSMAUP00000022823 | ENSMAUP00000017741 | Squalene synthase. | NADH dehydrogenase (Ubiquinone) complex I, assembly factor 6. | 0.629 |
Fdft1 | Ppox | ENSMAUP00000022823 | ENSMAUP00000016799 | Squalene synthase. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.868 |
Fdft1 | Pyroxd2 | ENSMAUP00000022823 | ENSMAUP00000019555 | Squalene synthase. | Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 2. | 0.978 |
Gale | Gpd2 | ENSMAUP00000017231 | ENSMAUP00000015742 | UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Glycerol-3-phosphate dehydrogenase, mitochondrial. | 0.568 |
Gale | Ppox | ENSMAUP00000017231 | ENSMAUP00000016799 | UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. | 0.886 |