STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Cdkn1cCyclin-dependent kinase inhibitor 1C isoform X2. (348 aa)    
Predicted Functional Partners:
Cdk2
Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...]
   
 0.993
Ccna2
Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. Belongs to the cyclin family. Cyclin AB subfamily.
    
 0.990
Cdk4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
   
 0.988
Skp2
S-phase kinase-associated protein 2.
    
 0.986
Ccne1
G1/S-specific cyclin-E1; Belongs to the cyclin family.
   
 0.986
Ccnd1
G1/S-specific cyclin-D1; Belongs to the cyclin family.
   
 0.985
Cdk6
Cyclin-dependent kinase 6.
   
 0.985
Ccne2
G1/S-specific cyclin-E2 isoform X1; Belongs to the cyclin family.
   
 0.973
Ccnd3
G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family.
   
 0.972
Ccnd2
G1/S-specific cyclin-D2; Belongs to the cyclin family.
   
 0.971
Your Current Organism:
Mesocricetus auratus
NCBI taxonomy Id: 10036
Other names: Golden hamsters, M. auratus, Syrian golden hamster, Syrian golden hamsters, Syrian hamster, Syrian hamsters, golden hamster
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