node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B2m | Cdk1 | ENSMAUP00000025837 | ENSMAUP00000023040 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | 0.707 |
B2m | Cdk2 | ENSMAUP00000025837 | ENSMAUP00000021672 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.728 |
B2m | H1f2 | ENSMAUP00000025837 | ENSMAUP00000020118 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Histone H1.2. | 0.723 |
B2m | H1f8 | ENSMAUP00000025837 | ENSMAUP00000010480 | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | Histone H1oo isoform X1. | 0.723 |
Cdk1 | B2m | ENSMAUP00000023040 | ENSMAUP00000025837 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | 0.707 |
Cdk1 | Cdk2 | ENSMAUP00000023040 | ENSMAUP00000021672 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | 0.930 |
Cdk1 | H1f2 | ENSMAUP00000023040 | ENSMAUP00000020118 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Histone H1.2. | 0.586 |
Cdk1 | H1f8 | ENSMAUP00000023040 | ENSMAUP00000010480 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Histone H1oo isoform X1. | 0.593 |
Cdk1 | LOC101825928 | ENSMAUP00000023040 | ENSMAUP00000005203 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Histone H4. | 0.593 |
Cdk1 | LOC101843531 | ENSMAUP00000023040 | ENSMAUP00000004358 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.593 |
Cdk1 | Rpa2 | ENSMAUP00000023040 | ENSMAUP00000002899 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Replication protein A 32 kDa subunit. | 0.707 |
Cdk1 | Sass6 | ENSMAUP00000023040 | ENSMAUP00000012857 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | Spindle assembly abnormal protein 6 homolog isoform X1. | 0.646 |
Cdk1 | Stn1 | ENSMAUP00000023040 | ENSMAUP00000016604 | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. | 0.635 |
Cdk2 | B2m | ENSMAUP00000021672 | ENSMAUP00000025837 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). | 0.728 |
Cdk2 | Cdk1 | ENSMAUP00000021672 | ENSMAUP00000023040 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Cyclin-dependent kinase 1 isoform X1; Belongs to the protein kinase superfamily. | 0.930 |
Cdk2 | H1f2 | ENSMAUP00000021672 | ENSMAUP00000020118 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Histone H1.2. | 0.632 |
Cdk2 | H1f8 | ENSMAUP00000021672 | ENSMAUP00000010480 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Histone H1oo isoform X1. | 0.593 |
Cdk2 | LOC101825928 | ENSMAUP00000021672 | ENSMAUP00000005203 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Histone H4. | 0.522 |
Cdk2 | LOC101843531 | ENSMAUP00000021672 | ENSMAUP00000004358 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.522 |
Cdk2 | Rpa2 | ENSMAUP00000021672 | ENSMAUP00000002899 | Cyclin-dependent kinase 2; Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK [...] | Replication protein A 32 kDa subunit. | 0.728 |