node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Exo1 | Fen1 | ENSMAUP00000018873 | ENSMAUP00000011960 | Exonuclease 1 isoform X1. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.935 |
Exo1 | LOC106021697 | ENSMAUP00000018873 | ENSMAUP00000005715 | Exonuclease 1 isoform X1. | DNA mismatch repair protein Msh6. | 0.994 |
Exo1 | Mlh1 | ENSMAUP00000018873 | ENSMAUP00000016434 | Exonuclease 1 isoform X1. | DNA mismatch repair protein Mlh1. | 0.998 |
Exo1 | Mlh3 | ENSMAUP00000018873 | ENSMAUP00000001129 | Exonuclease 1 isoform X1. | DNA mismatch repair protein Mlh3 isoform X3. | 0.888 |
Exo1 | Msh2 | ENSMAUP00000018873 | ENSMAUP00000021786 | Exonuclease 1 isoform X1. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.998 |
Exo1 | Msh3 | ENSMAUP00000018873 | ENSMAUP00000024927 | Exonuclease 1 isoform X1. | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.888 |
Exo1 | Pcna | ENSMAUP00000018873 | ENSMAUP00000009744 | Exonuclease 1 isoform X1. | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.995 |
Exo1 | Pms1 | ENSMAUP00000018873 | ENSMAUP00000020657 | Exonuclease 1 isoform X1. | PMS1 protein homolog 1. | 0.958 |
Exo1 | Pms2 | ENSMAUP00000018873 | ENSMAUP00000014177 | Exonuclease 1 isoform X1. | Mismatch repair endonuclease PMS2. | 0.994 |
Exo1 | Pold1 | ENSMAUP00000018873 | ENSMAUP00000003562 | Exonuclease 1 isoform X1. | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.950 |
Fen1 | Exo1 | ENSMAUP00000011960 | ENSMAUP00000018873 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Exonuclease 1 isoform X1. | 0.935 |
Fen1 | LOC106021697 | ENSMAUP00000011960 | ENSMAUP00000005715 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein Msh6. | 0.948 |
Fen1 | Mlh1 | ENSMAUP00000011960 | ENSMAUP00000016434 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein Mlh1. | 0.896 |
Fen1 | Mlh3 | ENSMAUP00000011960 | ENSMAUP00000001129 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein Mlh3 isoform X3. | 0.850 |
Fen1 | Msh2 | ENSMAUP00000011960 | ENSMAUP00000021786 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.970 |
Fen1 | Msh3 | ENSMAUP00000011960 | ENSMAUP00000024927 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). | 0.887 |
Fen1 | Pcna | ENSMAUP00000011960 | ENSMAUP00000009744 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. | 0.999 |
Fen1 | Pms1 | ENSMAUP00000011960 | ENSMAUP00000020657 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | PMS1 protein homolog 1. | 0.828 |
Fen1 | Pms2 | ENSMAUP00000011960 | ENSMAUP00000014177 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Mismatch repair endonuclease PMS2. | 0.878 |
Fen1 | Pold1 | ENSMAUP00000011960 | ENSMAUP00000003562 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA polymerase delta catalytic subunit; As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex), plays a crucial role in high fidelity genome replication, including in lagging strand synthesis, and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities. Requires the presence of accessory proteins POLD2, POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol- delta4), displays differences in catalytic activity. Most notably, expresses higher pro [...] | 0.999 |