node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carA | carB | BUAMB_133 | BUAMB_132 | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. | Carbamoyl phosphate synthase large subunit; Belongs to the CarB family. | 0.999 |
carA | folA | BUAMB_133 | BUAMB_131 | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.547 |
carA | purH | BUAMB_133 | BUAMB_030 | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.560 |
carA | thrA | BUAMB_133 | BUAMB_182 | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. | Bifunctional aspartokinase I/homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.496 |
carB | carA | BUAMB_132 | BUAMB_133 | Carbamoyl phosphate synthase large subunit; Belongs to the CarB family. | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. | 0.999 |
carB | folA | BUAMB_132 | BUAMB_131 | Carbamoyl phosphate synthase large subunit; Belongs to the CarB family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.574 |
carB | ribD1 | BUAMB_132 | BUAMB_435 | Carbamoyl phosphate synthase large subunit; Belongs to the CarB family. | Riboflavin deaminase; APS ortholog shorter than E. coli, ribD1/2 fused in E. coli. | 0.653 |
carB | thrA | BUAMB_132 | BUAMB_182 | Carbamoyl phosphate synthase large subunit; Belongs to the CarB family. | Bifunctional aspartokinase I/homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.436 |
fmt | folA | BUAMB_472 | BUAMB_131 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.923 |
fmt | glyA | BUAMB_472 | BUAMB_270 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
fmt | ribD1 | BUAMB_472 | BUAMB_435 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Riboflavin deaminase; APS ortholog shorter than E. coli, ribD1/2 fused in E. coli. | 0.423 |
fmt | thyA | BUAMB_472 | BUAMB_415 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.459 |
folA | carA | BUAMB_131 | BUAMB_133 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Carbamoyl phosphate synthase small subunit; Belongs to the CarA family. | 0.547 |
folA | carB | BUAMB_131 | BUAMB_132 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Carbamoyl phosphate synthase large subunit; Belongs to the CarB family. | 0.574 |
folA | fmt | BUAMB_131 | BUAMB_472 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.923 |
folA | folC | BUAMB_131 | BUAMB_155 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate synthase; Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10- formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives. | 0.924 |
folA | glyA | BUAMB_131 | BUAMB_270 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
folA | pheA | BUAMB_131 | BUAMB_368 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Chorismate mutase. | 0.697 |
folA | purH | BUAMB_131 | BUAMB_030 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.913 |
folA | ribD1 | BUAMB_131 | BUAMB_435 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Riboflavin deaminase; APS ortholog shorter than E. coli, ribD1/2 fused in E. coli. | 0.490 |