node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
gcvP | purC | GBAG_3400 | GBAG_3020 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | 0.754 |
gcvP | purD | GBAG_3400 | GBAG_0109 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Protein involved in phosphoribosylamine-glycine ligase activity, purine nucleotide biosynthetic process, purine nucleobase biosynthetic process and cellular response to DNA damage stimulus; Belongs to the GARS family. | 0.945 |
gcvP | purE | GBAG_3400 | GBAG_0920 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.640 |
gcvP | purF | GBAG_3400 | GBAG_2896 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.814 |
gcvP | purH | GBAG_3400 | GBAG_0110 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Protein involved in IMP cyclohydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, catalytic activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process. | 0.791 |
gcvP | purL | GBAG_3400 | GBAG_3105 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Glutamine amidotransferase subunit of phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.937 |
gcvP | purM | GBAG_3400 | GBAG_3031 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Protein involved in catalytic activity, phosphoribosylformylglycinamidine cyclo-ligase activity and 'de novo' IMP biosynthetic process. | 0.430 |
gcvP | purN | GBAG_3400 | GBAG_3032 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.426 |
gcvP | purT | GBAG_3400 | GBAG_2313 | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.539 |
purC | gcvP | GBAG_3020 | GBAG_3400 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.754 |
purC | purD | GBAG_3020 | GBAG_0109 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Protein involved in phosphoribosylamine-glycine ligase activity, purine nucleotide biosynthetic process, purine nucleobase biosynthetic process and cellular response to DNA damage stimulus; Belongs to the GARS family. | 0.976 |
purC | purE | GBAG_3020 | GBAG_0920 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). | 0.998 |
purC | purF | GBAG_3020 | GBAG_2896 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.959 |
purC | purH | GBAG_3020 | GBAG_0110 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Protein involved in IMP cyclohydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, catalytic activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process. | 0.973 |
purC | purK | GBAG_3020 | GBAG_0919 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). | 0.988 |
purC | purL | GBAG_3020 | GBAG_3105 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Glutamine amidotransferase subunit of phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.989 |
purC | purM | GBAG_3020 | GBAG_3031 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Protein involved in catalytic activity, phosphoribosylformylglycinamidine cyclo-ligase activity and 'de novo' IMP biosynthetic process. | 0.977 |
purC | purN | GBAG_3020 | GBAG_3032 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.969 |
purC | purT | GBAG_3020 | GBAG_2313 | Protein involved in phosphoribosylaminoimidazolesuccinocarboxamide synthase activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process; Belongs to the SAICAR synthetase family. | Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. | 0.682 |
purD | gcvP | GBAG_0109 | GBAG_3400 | Protein involved in phosphoribosylamine-glycine ligase activity, purine nucleotide biosynthetic process, purine nucleobase biosynthetic process and cellular response to DNA damage stimulus; Belongs to the GARS family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.945 |