STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceBProtein involved in malate synthase activity, catalytic activity, tricarboxylic acid cycle and glyoxylate cycle; Belongs to the malate synthase family. (532 aa)    
Predicted Functional Partners:
aceA
Isocitrate lyase; Protein involved in catalytic activity, isocitrate lyase activity, tricarboxylic acid cycle, metabolic process and carboxylic acid metabolic process.
 
 0.999
maeB
NADP-dependent malic enzyme; Protein involved in malate dehydrogenase (decarboxylating) (NAD+) activity, transferase activity, transferring acyl groups, NAD binding, oxidation-reduction process and metabolic process.
  
 
 0.974
gltA
Citrate (Si)-synthase; Protein involved in transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer, citrate (Si)-synthase activity, tricarboxylic acid cycle and cellular carbohydrate metabolic process.
   
 0.969
pta
Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.969
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. Enables the cell to use acetate during aerobic growth to generate energy via the TCA cycle, and biosynthetic compounds via the glyoxylate shunt. A [...]
   
 0.961
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
   
 0.941
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
    
 0.936
fumA
Fumarate hydratase class I, aerobic; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
    
 0.935
gcl
Glyoxylate carboligase; Protein involved in thiamine pyrophosphate binding, magnesium ion binding, catalytic activity, tartronate-semialdehyde synthase activity and glyoxylate catabolic process; Belongs to the TPP enzyme family.
    
 0.924
GBAG_3333
3-ketoacyl-CoA thiolase/acetyl-CoA acetyltransferase; Protein involved in transferase activity, transferring acyl groups other than amino-acyl groups, catalytic activity, fatty acid metabolic process and metabolic process; Belongs to the thiolase-like superfamily. Thiolase family.
   
 
 0.924
Your Current Organism:
Buttiauxella agrestis
NCBI taxonomy Id: 1006004
Other names: B. agrestis ATCC 33320, Buttiauxella agrestis ATCC 33320, Buttiauxella agrestis CDC 11786-81, Buttiauxella agrestis CIP 80.31, Buttiauxella agrestis CUETM 77-167, Buttiauxella agrestis DSM 4586, Buttiauxella agrestis str. ATCC 33320, Buttiauxella agrestis strain ATCC 33320
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.