STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)    
Predicted Functional Partners:
leuC
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 
 
 0.999
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.942
poxB
Thiamine pyrophosphate enzyme; Protein involved in magnesium ion binding, thiamine pyrophosphate binding, catalytic activity and oxidation-reduction process; Belongs to the TPP enzyme family.
 
 
 0.903
IlvD
Dihydroxy-acid dehydratase; Protein involved in catalytic activity, dihydroxy-acid dehydratase activity, isoleucine biosynthetic process, valine biosynthetic process, metabolic process and branched-chain amino acid biosynthetic process; Belongs to the IlvD/Edd family.
 
  
 0.892
ilvD
Dihydroxy-acid dehydratase; Protein involved in catalytic activity, dihydroxy-acid dehydratase activity, isoleucine biosynthetic process, valine biosynthetic process, metabolic process and branched-chain amino acid biosynthetic process; Belongs to the IlvD/Edd family.
 
  
 0.872
IlvN
Protein involved in acetolactate synthase activity, isoleucine biosynthetic process, valine biosynthetic process and branched-chain amino acid biosynthetic process.
 
  
 0.869
GBAG_0989
Tartrate dehydrogenase/tartrate decarboxylase/D-malic enzyme; Protein involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, NAD binding, magnesium ion binding, carboxylic acid catabolic process and oxidation-reduction process.
 
  
 0.868
acnA
Aconitate hydratase/2-methylisocitrate dehydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 
 0.861
Your Current Organism:
Buttiauxella agrestis
NCBI taxonomy Id: 1006004
Other names: B. agrestis ATCC 33320, Buttiauxella agrestis ATCC 33320, Buttiauxella agrestis CDC 11786-81, Buttiauxella agrestis CIP 80.31, Buttiauxella agrestis CUETM 77-167, Buttiauxella agrestis DSM 4586, Buttiauxella agrestis str. ATCC 33320, Buttiauxella agrestis strain ATCC 33320
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