node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GBAG_1290 | yadH | GBAG_1290 | GBAG_0628 | FIG00613574; Protein involved in biological_process. | Permease component of an ABC superfamily multidrug transporter. | 0.526 |
GBAG_1290 | ydjA | GBAG_1290 | GBAG_1537 | FIG00613574; Protein involved in biological_process. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.591 |
GBAG_1534 | sppA | GBAG_1534 | GBAG_1536 | Nicotinamidase; Protein involved in catalytic activity and metabolic process. | Protease IV; Protein involved in peptidase activity, proteolysis and signal peptide processing. | 0.568 |
GBAG_1534 | ydjA | GBAG_1534 | GBAG_1537 | Nicotinamidase; Protein involved in catalytic activity and metabolic process. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.434 |
GBAG_1540 | selD | GBAG_1540 | GBAG_1538 | Protein involved in biological_process. | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | 0.794 |
GBAG_1540 | topB | GBAG_1540 | GBAG_1539 | Protein involved in biological_process. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.786 |
GBAG_1540 | ydjA | GBAG_1540 | GBAG_1537 | Protein involved in biological_process. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.552 |
birA | cysG | GBAG_0080 | GBAG_3816 | Biotin-protein ligase/biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.537 |
birA | ydjA | GBAG_0080 | GBAG_1537 | Biotin-protein ligase/biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.635 |
cysG | birA | GBAG_3816 | GBAG_0080 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | Biotin-protein ligase/biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.537 |
cysG | metH | GBAG_3816 | GBAG_0118 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.637 |
cysG | ydjA | GBAG_3816 | GBAG_1537 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.489 |
metH | cysG | GBAG_0118 | GBAG_3816 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.637 |
metH | ydjA | GBAG_0118 | GBAG_1537 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.434 |
selD | GBAG_1540 | GBAG_1538 | GBAG_1540 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | Protein involved in biological_process. | 0.794 |
selD | topB | GBAG_1538 | GBAG_1539 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.794 |
selD | ydjA | GBAG_1538 | GBAG_1537 | Selenide, water dikinase; Synthesizes selenophosphate from selenide and ATP. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.623 |
sppA | GBAG_1534 | GBAG_1536 | GBAG_1534 | Protease IV; Protein involved in peptidase activity, proteolysis and signal peptide processing. | Nicotinamidase; Protein involved in catalytic activity and metabolic process. | 0.568 |
sppA | topB | GBAG_1536 | GBAG_1539 | Protease IV; Protein involved in peptidase activity, proteolysis and signal peptide processing. | DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...] | 0.431 |
sppA | ydjA | GBAG_1536 | GBAG_1537 | Protease IV; Protein involved in peptidase activity, proteolysis and signal peptide processing. | YdjA family protein; Protein involved in oxidoreductase activity and oxidation-reduction process. | 0.542 |