node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GBAG_1065 | hisA | GBAG_1065 | GBAG_2589 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | 0.829 |
GBAG_1065 | hisB | GBAG_1065 | GBAG_2587 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | Protein involved in imidazoleglycerol-phosphate dehydratase activity, phosphatase activity, histidinol-phosphatase activity and histidine biosynthetic process. | 0.971 |
GBAG_1065 | hisD | GBAG_1065 | GBAG_2585 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.776 |
GBAG_1065 | hisD-2 | GBAG_1065 | GBAG_1630 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.730 |
GBAG_1065 | hisD-3 | GBAG_1065 | GBAG_1635 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.775 |
GBAG_1065 | hisE | GBAG_1065 | GBAG_2591 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase; Protein involved in phosphoribosyl-AMP cyclohydrolase activity, phosphoribosyl-ATP diphosphatase activity and histidine biosynthetic process; In the N-terminal section; belongs to the PRA-CH family. | 0.966 |
GBAG_1065 | hisF | GBAG_1065 | GBAG_2590 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.838 |
GBAG_1065 | hisG | GBAG_1065 | GBAG_2584 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.827 |
GBAG_1065 | hisH | GBAG_1065 | GBAG_2588 | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.848 |
hisA | GBAG_1065 | GBAG_2589 | GBAG_1065 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | 0.829 |
hisA | hisB | GBAG_2589 | GBAG_2587 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | Protein involved in imidazoleglycerol-phosphate dehydratase activity, phosphatase activity, histidinol-phosphatase activity and histidine biosynthetic process. | 0.997 |
hisA | hisC | GBAG_2589 | GBAG_2586 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | Protein involved in pyridoxal phosphate binding, histidinol-phosphate transaminase activity, histidine biosynthetic process and biosynthetic process; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.993 |
hisA | hisD | GBAG_2589 | GBAG_2585 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.985 |
hisA | hisD-2 | GBAG_2589 | GBAG_1630 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.924 |
hisA | hisD-3 | GBAG_2589 | GBAG_1635 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.934 |
hisA | hisE | GBAG_2589 | GBAG_2591 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase; Protein involved in phosphoribosyl-AMP cyclohydrolase activity, phosphoribosyl-ATP diphosphatase activity and histidine biosynthetic process; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisF | GBAG_2589 | GBAG_2590 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | GBAG_2589 | GBAG_2584 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.995 |
hisA | hisH | GBAG_2589 | GBAG_2588 | Protein involved in 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase activity, catalytic activity, histidine biosynthetic process and metabolic process. | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | GBAG_1065 | GBAG_2587 | GBAG_1065 | Protein involved in imidazoleglycerol-phosphate dehydratase activity, phosphatase activity, histidinol-phosphatase activity and histidine biosynthetic process. | L-threonine 3-O-phosphate decarboxylase; Protein involved in pyridoxal phosphate binding, catalytic activity, cobalamin biosynthetic process and biosynthetic process. | 0.971 |