node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
fdx | hscA | GBAG_3082 | GBAG_3083 | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.981 |
fdx | hscB | GBAG_3082 | GBAG_3084 | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.993 |
fdx | iscA | GBAG_3082 | GBAG_3085 | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | IscA family iron-binding iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.960 |
fdx | iscR | GBAG_3082 | GBAG_3088 | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | Iron-sulfur cluster regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.681 |
fdx | iscS | GBAG_3082 | GBAG_3087 | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | IscS family cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.974 |
fdx | iscX | GBAG_3082 | GBAG_3081 | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | Protein involved in iron-sulfur cluster assembly. | 0.993 |
fdx | nifU | GBAG_3082 | GBAG_3086 | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | Iron-sulfur cluster assembly scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.988 |
hscA | fdx | GBAG_3083 | GBAG_3082 | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | 0.981 |
hscA | hscB | GBAG_3083 | GBAG_3084 | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.993 |
hscA | iscA | GBAG_3083 | GBAG_3085 | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | IscA family iron-binding iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.881 |
hscA | iscR | GBAG_3083 | GBAG_3088 | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Iron-sulfur cluster regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.515 |
hscA | iscS | GBAG_3083 | GBAG_3087 | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | IscS family cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.906 |
hscA | iscX | GBAG_3083 | GBAG_3081 | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Protein involved in iron-sulfur cluster assembly. | 0.961 |
hscA | nifU | GBAG_3083 | GBAG_3086 | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | Iron-sulfur cluster assembly scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.974 |
hscB | fdx | GBAG_3084 | GBAG_3082 | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 2Fe-2S ferredoxin; Protein involved in electron carrier activity, iron-sulfur cluster binding, 2 iron, 2 sulfur cluster binding and iron-sulfur cluster assembly. | 0.993 |
hscB | hscA | GBAG_3084 | GBAG_3083 | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | HscA family chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. | 0.993 |
hscB | iscA | GBAG_3084 | GBAG_3085 | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | IscA family iron-binding iron-sulfur cluster assembly protein; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. | 0.969 |
hscB | iscR | GBAG_3084 | GBAG_3088 | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster regulator; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.922 |
hscB | iscS | GBAG_3084 | GBAG_3087 | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | IscS family cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. | 0.978 |
hscB | iscX | GBAG_3084 | GBAG_3081 | HscB family chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Protein involved in iron-sulfur cluster assembly. | 0.981 |