node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GBAG_2270 | GBAG_3274 | GBAG_2270 | GBAG_3274 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.903 |
GBAG_2270 | gcvP | GBAG_2270 | GBAG_3400 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.648 |
GBAG_2270 | gcvT | GBAG_2270 | GBAG_3402 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.425 |
GBAG_2270 | glyA | GBAG_2270 | GBAG_3099 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
GBAG_3274 | GBAG_2270 | GBAG_3274 | GBAG_2270 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.903 |
GBAG_3274 | gcvP | GBAG_3274 | GBAG_3400 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.650 |
GBAG_3274 | gcvT | GBAG_3274 | GBAG_3402 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.425 |
GBAG_3274 | glyA | GBAG_3274 | GBAG_3099 | Protein involved in L-serine ammonia-lyase activity, 4 iron, 4 sulfur cluster binding, cellular amino acid catabolic process and gluconeogenesis; Belongs to the iron-sulfur dependent L-serine dehydratase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.949 |
folD | gcvH | GBAG_1017 | GBAG_3401 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.580 |
folD | gcvP | GBAG_1017 | GBAG_3400 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.745 |
folD | gcvT | GBAG_1017 | GBAG_3402 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.963 |
folD | glyA | GBAG_1017 | GBAG_3099 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.983 |
folD | metF | GBAG_1017 | GBAG_4290 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Protein involved in methylenetetrahydrofolate reductase (NAD(P)H) activity, methionine biosynthetic process, methionine metabolic process and oxidation-reduction process. | 0.940 |
folD | purH | GBAG_1017 | GBAG_0110 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Protein involved in IMP cyclohydrolase activity, phosphoribosylaminoimidazolecarboxamide formyltransferase activity, catalytic activity, purine ribonucleotide biosynthetic process and purine nucleotide biosynthetic process. | 0.972 |
folD | purL | GBAG_1017 | GBAG_3105 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glutamine amidotransferase subunit of phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.804 |
folD | purN | GBAG_1017 | GBAG_3032 | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.973 |
gcvH | folD | GBAG_3401 | GBAG_1017 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.580 |
gcvH | gcvP | GBAG_3401 | GBAG_3400 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.999 |
gcvH | gcvT | GBAG_3401 | GBAG_3402 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
gcvH | glyA | GBAG_3401 | GBAG_3099 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.971 |