STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lsrBPeriplasmic substrate-binding component of an ABC superfamily autoinducer 2 (AI-2) transporter. (339 aa)    
Predicted Functional Partners:
GBAG_3593
Membrane component of an ABC superfamily autoinducer 2 (AI-2) transporter; Protein involved in transporter activity and transport; Belongs to the binding-protein-dependent transport system permease family.
 0.995
GBAG_3594
Membrane channel component of an ABC superfamily autoinducer 2 (AI-2) transporter; Protein involved in transporter activity and transport; Belongs to the binding-protein-dependent transport system permease family.
 0.990
lsrF
Autoinducer 2 (AI-2) aldolase; Protein involved in lyase activity and biological_process.
 
  
 0.978
LsrA
ATP-binding component of an ABC superfamily autoinducer 2 (AI-2) transporter; Protein involved in ATP binding, ATPase activity, nucleotide binding, nucleoside-triphosphatase activity and heme transport.
 
 0.976
lsrG
Autoinducer 2 (AI-2) modifying protein; Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the conversion of (4S)-4-hydroxy-5- phosphonooxypentane-2,3-dione (P-DPD) to 3-hydroxy-5- phosphonooxypentane-2,4-dione (P-HPD); Belongs to the LsrG family.
 
  
 0.974
lsrK
Autoinducer 2 (AI-2) kinase; Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3-dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position.
 
  
 0.915
lsrR
Lsr operon transcriptional repressor; Protein involved in carbohydrate binding and (DEPRECATED) transcription.
 
  
 0.908
barA
Sensory histidine kinase; Protein involved in signal transducer activity, ATP binding, phosphorelay response regulator activity, phosphorelay sensor kinase activity, peptidyl-histidine phosphorylation, regulation of transcription, DNA-templated, response to hydrogen peroxide, protein autophosphorylation, (DEPRECATED) transcription, signal transduction and phosphorelay signal transduction system.
  
 
 0.835
GBAG_3908
Membrane component of a predicted ABC superfamily L-rhamnose transporter; Protein involved in transporter activity and transport; Belongs to the binding-protein-dependent transport system permease family.
 
 0.832
evgS
Two-component regulatory system hybrid sensory histidine kinase; Protein involved in ATP binding, phosphorelay response regulator activity, signal transducer activity, phosphorelay sensor kinase activity, transporter activity, peptidyl-histidine phosphorylation, regulation of transcription, DNA-templated, protein autophosphorylation, phosphorelay signal transduction system, signal transduction and transport.
  
 
 0.829
Your Current Organism:
Buttiauxella agrestis
NCBI taxonomy Id: 1006004
Other names: B. agrestis ATCC 33320, Buttiauxella agrestis ATCC 33320, Buttiauxella agrestis CDC 11786-81, Buttiauxella agrestis CIP 80.31, Buttiauxella agrestis CUETM 77-167, Buttiauxella agrestis DSM 4586, Buttiauxella agrestis str. ATCC 33320, Buttiauxella agrestis strain ATCC 33320
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