STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metLAspartokinase/homoserine dehydrogenase; Protein involved in oxidoreductase activity, NADP binding, aspartate kinase activity, oxidation-reduction process, lysine biosynthetic process via diaminopimelate, homoserine biosynthetic process, methionine biosynthetic process, cellular amino acid metabolic process and cellular amino acid biosynthetic process; In the C-terminal section; belongs to the homoserine dehydrogenase family. (810 aa)    
Predicted Functional Partners:
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 0.998
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
 0.992
metB
Cystathionine gamma-synthase; Protein involved in pyridoxal phosphate binding.
 
 
 0.992
thrC
Protein involved in threonine biosynthetic process.
 
 
 0.978
metA
Homoserine O-succinyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family.
  
 
 0.970
metH
5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
  
 
 0.966
thrA
Aspartokinase/homoserine dehydrogenase; Protein involved in oxidoreductase activity, NADP binding, aspartate kinase activity, threonine biosynthetic process, oxidation-reduction process, lysine biosynthetic process via diaminopimelate, homoserine biosynthetic process, cellular amino acid metabolic process and cellular amino acid biosynthetic process; In the C-terminal section; belongs to the homoserine dehydrogenase family.
 
0.961
LysC
Aspartokinase; Protein involved in amino acid binding, aspartate kinase activity, lysine biosynthetic process via diaminopimelate, metabolic process and cellular amino acid biosynthetic process; Belongs to the aspartokinase family.
 
0.960
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.960
asnB
Protein involved in asparagine synthase (glutamine-hydrolyzing) activity, asparagine biosynthetic process and metabolic process.
 
 
 0.952
Your Current Organism:
Buttiauxella agrestis
NCBI taxonomy Id: 1006004
Other names: B. agrestis ATCC 33320, Buttiauxella agrestis ATCC 33320, Buttiauxella agrestis CDC 11786-81, Buttiauxella agrestis CIP 80.31, Buttiauxella agrestis CUETM 77-167, Buttiauxella agrestis DSM 4586, Buttiauxella agrestis str. ATCC 33320, Buttiauxella agrestis strain ATCC 33320
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