Known metabolic pathways, protein complexes, signal transduction pathways, etc ... from curated databases.
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Fusion
Genes that are sometimes fused into single open reading frames.
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Textmining
Automated, unsupervised textmining - searching for proteins that are frequently mentioned together.
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Coexpression
Proteins whose genes are observed to be correlated in expression, across a large number of experiments.
STRING allows inspection of the interaction evidence for any given network. Choose any of the viewers above (disabled if not applicable in your network).
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes: query proteins and first shell of interactors
white nodes: second shell of interactors
Node Content
empty nodes: proteins of unknown 3D structure
filled nodes: a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GBAG_4335
Protein involved in biological_process. (55 aa)
Predicted Functional Partners:
GBAG_4334
TraT family plasmid conjugative transfer surface exclusion protein; Responsible for preventing unproductive conjugation between bacteria carrying like plasmids; Belongs to the TraT lipoprotein family.
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
node1
node2
node1 annotation
node2 annotation
score
GBAG_4334
GBAG_4335
TraT family plasmid conjugative transfer surface exclusion protein; Responsible for preventing unproductive conjugation between bacteria carrying like plasmids; Belongs to the TraT lipoprotein family.
Protein involved in biological_process.
0.461
GBAG_4335
GBAG_4334
Protein involved in biological_process.
TraT family plasmid conjugative transfer surface exclusion protein; Responsible for preventing unproductive conjugation between bacteria carrying like plasmids; Belongs to the TraT lipoprotein family.
0.461
Network Stats
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Functional enrichments in your networkNote: some enrichments may be expected here (why?) disable highlightexplain columns
Enrichment analysis is still ongoing, please wait ...
Statistical background
For the above enrichment analysis, the following statistical background is assumed: