STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrAHomoserine dehydrogenase; High confidence in function and specificity. (426 aa)    
Predicted Functional Partners:
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 0.997
thrC
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
 0.992
asd
Aspartate-semialdehyde dehydrogenase; High confidence in function and specificity; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
 0.969
metA
Homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family.
  
 
 0.946
metH
Methionine synthase I (cobalamin-dependent); Amino acid transport and metabolism; High confidence in function and specificity.
  
 
 0.940
dapA1
N-acetylneuraminate lyase; Family membership; Belongs to the DapA family.
  
 
 0.919
dapA5
4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
  
 
 0.919
lysC
Aspartokinase; Aspartate kinase catalyzes a first step in the biosynthesis from Asp of Lys (and its precursor diaminopimelate), Met, and Thr; High confidence in function and specificity; Belongs to the aspartokinase family.
 
 0.900
ilvE
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Is a multifunctional enzyme that carries out the final step in valine, leucine and isoleucine biosyntheses. IlvE catalyzes three reversible transamination reactions, each of which generates alpha-ketoglutarate and one of three aliphatic amino acids; High confidence in function and specificity.
  
 
 0.897
DTL3_0209
O-acetylhomoserine sulfhydrylase; High confidence in function and specificity.
  
 
 0.864
Your Current Organism:
Defluviitoga tunisiensis
NCBI taxonomy Id: 1006576
Other names: D. tunisiensis, DSM 23805, Defluviitoga tunisiensis Ben Hania et al. 2012, JCM 17210, Thermotogaceae bacterium SulfLac1, strain SulfLac1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.