STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
clpP3Caseinolytic protease; ATP-dependent, highly conserved serine protease.Clp proteases are involved in a number of cellular processes such as degradation of misfolded proteins, regulation of short-lived proteins and housekeeping removal of dysfunctional proteins; High confidence in function and specificity; Belongs to the peptidase S14 family. (242 aa)    
Predicted Functional Partners:
DTL3_1131
Phage portal protein, HK97 family; The portal complex forms a channel through which the viral DNA is packaged into the capsid, and exits during infection; High confidence in function and specificity.
  
 0.991
clpX
ATP-dependent Clp protease, ATP-binding subunit; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.
 
 
 0.956
DTL3_1133
Phage phi-C31 gp36 major capsid protein; The gene encoding this component is typically located in an operon encoding the small and large terminase subunits, the portal protein and the prohead or maturation protease; High confidence in function and specificity.
 
    0.917
clpB
Chaperone protein ClpB; High confidence in function and specificity; Belongs to the ClpA/ClpB family.
  
 
 0.899
clpC
ATP-dependent Clp protease, subunit C; Chaperones and folding catalysts; High confidence in function and specificity; Belongs to the ClpA/ClpB family.
  
 
 0.899
DTL3_1129
Large subunit; The terminase is involved in site-specific binding and cutting of the DNA; High confidence in function and specificity.
 
   
 0.787
DTL3_1119
The terminase is composed of two small and one large subunits. To initiate packaging, it binds a specific sequence called cos, at the junction of adjacent viral genomes in the concatemeric DNA substrate; High confidence in function and specificity.
 
    0.785
hrcA
Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
   
  
 0.757
DTL3_1122
ParB domain protein nuclease; ParB preferentially cleaves single-stranded DNA; High confidence in function and specificity; Belongs to the N(4)/N(6)-methyltransferase family.
 
   
 0.734
DTL3_1121
DNA methylase; The family contains both N-4 cytosine-specific DNA methylases and N-6 Adenine-specific DNA methylases; High confidence in function and specificity; Belongs to the N(4)/N(6)-methyltransferase family.
 
   
 0.699
Your Current Organism:
Defluviitoga tunisiensis
NCBI taxonomy Id: 1006576
Other names: D. tunisiensis, DSM 23805, Defluviitoga tunisiensis Ben Hania et al. 2012, JCM 17210, Thermotogaceae bacterium SulfLac1, strain SulfLac1
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