STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (322 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; D-glucose 6-phosphate <=> D-fructose 6-phosphate; High confidence in function and specificity; Belongs to the GPI family.
  
 0.969
fba
Fructose-bisphosphate aldolase; High confidence in function and specificity.
  
 
 0.929
pyk
Pyruvate kinase; Glycolysis/gluconeogenesis; High confidence in function and specificity; Belongs to the pyruvate kinase family.
 
 0.929
manA
Mannose-6-phosphate isomerase type I; Is an enzyme which facilitates the interconversion of fructose 6-phosphate(F6P) and mannose-6-phosphate(M6P); High confidence in function and specificity.
 
  
 0.921
tktA
Transketolase; It catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to an aldose receptor, such as ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. This enzyme, together with transaldolase, provides a link between the glycolytic and pentose-phosphate pathways; High confidence in function and specificity.
  
 
 0.919
pfk3
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family.
  
  
 
0.917
DTL3_0428
Fructose-bisphosphate aldolase; High confidence in function and specificity.
    
 0.916
mipB
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.916
glpX
Fructose 1,6-bisphosphatase; High confidence in function and specificity; Belongs to the FBPase class 2 family.
   
 
 0.913
scrK
Fructokinasae; Fructose and mannose metabolism; High confidence in function and specificity.
  
 
 0.907
Your Current Organism:
Defluviitoga tunisiensis
NCBI taxonomy Id: 1006576
Other names: D. tunisiensis, DSM 23805, Defluviitoga tunisiensis Ben Hania et al. 2012, JCM 17210, Thermotogaceae bacterium SulfLac1, strain SulfLac1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.