STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
phoU1-2Phosphate-specific transport system accessory protein PhoU homolog 1; Plays a role in the regulation of phosphate uptake. (220 aa)    
Predicted Functional Partners:
pstA
Phosphate ABC transporter, inner membrane subunit; ABC-type phosphate transport system, permease component; High confidence in function and specificity.
  
 0.976
pstB
Phosphate import ATP-binding protein PstB; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.
  
 0.958
pstS3
Phosphate binding protein; Most are found in phosphate ABC-transporter operons, but some are found in phosphate regulatory operons; High confidence in function and specificity.
 
  
 0.922
pstS1
Substrate binding domain of putative ABC-type phosphate transporter; High confidence in function and specificity.
 
  
 0.858
pstC
Phosphate ABC transporter, permease subunit PstC; High confidence in function and specificity.
 
  
 0.827
phoB
PhoB is a DNA-binding response regulator protein acting with PhoR in a 2-component system responding to phosphate ion. PhoB acts as a positive regulator of gene expression for phosphate-related genes such as phoA, phoS, phoE and ugpAB as well as itself; High confidence in function and specificity.
  
  
 0.749
phoR
Phosphate regulon sensor kinase PhoR; The phoR gene usually is adjacent to the response regulator phoB gene; High confidence in function and specificity.
  
  
 0.747
DTL3_0891
Phosphate transporter ATP-binding protein; High confidence in function and specificity.
 
     0.552
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family.
     
 0.489
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.447
Your Current Organism:
Defluviitoga tunisiensis
NCBI taxonomy Id: 1006576
Other names: D. tunisiensis, DSM 23805, Defluviitoga tunisiensis Ben Hania et al. 2012, JCM 17210, Thermotogaceae bacterium SulfLac1, strain SulfLac1
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