AKP67846.1 protein (Lactobacillus ginsenosidimutans)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

AKP67846.1

Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)

Predicted Functional Partners:

AKP67804.1

0.955

AKP67844.1

0.667

AKP67845.1

0.667

AKP67218.1

0.536

Your Current Organism:

Lactobacillus ginsenosidimutans

NCBI taxonomy Id: 1007676
Other names: L. ginsenosidimutans, Lactobacillus sp. EMML 3041, strain EMML 3041

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKP67218.1	AKP67846.1	ABM34_06490	ABM34_10100	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.536
AKP67804.1	AKP67846.1	ABM34_09850	ABM34_10100	Plastocyanin; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.955
AKP67844.1	AKP67845.1	ABM34_10090	ABM34_10095	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
AKP67844.1	AKP67846.1	ABM34_10090	ABM34_10100	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.667
AKP67845.1	AKP67844.1	ABM34_10095	ABM34_10090	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.981
AKP67845.1	AKP67846.1	ABM34_10095	ABM34_10100	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.667
AKP67846.1	AKP67218.1	ABM34_10100	ABM34_06490	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.536
AKP67846.1	AKP67804.1	ABM34_10100	ABM34_09850	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Plastocyanin; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.955
AKP67846.1	AKP67844.1	ABM34_10100	ABM34_10090	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.667
AKP67846.1	AKP67845.1	ABM34_10100	ABM34_10095	Hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug ABC transporter ATP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.667

Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.819

expected number of edges:

14

PPI enrichment p-value:

0.000122

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006220

Pyrimidine nucleotide metabolic process

3 of 20

1.63

1.03

0.0071

GO:0006753

Nucleoside phosphate metabolic process

6 of 121

1.15

0.97

0.0013

GO:0009148

Pyrimidine nucleoside triphosphate biosynthetic process

2 of 7

1.91

0.82

0.0269

GO:0009117

Nucleotide metabolic process

5 of 118

1.08

0.8

0.0047

GO:1901292

Nucleoside phosphate catabolic process

2 of 8

1.85

0.79

0.0308

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016728

Oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

3 of 6

2.16

1.43

0.0019

GO:0004748

Ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor

2 of 4

2.16

0.92

0.0194

GO:0019205

Nucleobase-containing compound kinase activity

2 of 9

1.8

0.76

0.0336

GO:0016776

Phosphotransferase activity, phosphate group as acceptor

2 of 12

1.68

0.73

0.0370

GO:0000166

Nucleotide binding

8 of 492

0.67

0.47

0.0095

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005971

Ribonucleoside-diphosphate reductase complex

2 of 3

2.28

0.98

0.0158

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:836

Oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor, and dUTPase

4 of 12

1.98

2.16

3.36e-05

CL:5199

Mixed, incl. Putative zinc- or iron-chelating domain, and Nucleoside triphosphate catabolic process

3 of 5

2.23

1.92

0.00021

CL:734

Mixed, incl. Nucleoside monophosphate biosynthetic process, and Oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor

6 of 63

1.43

1.65

2.63e-05

CL:838

Ribonucleoside-diphosphate reductase activity

2 of 5

2.06

0.93

0.0180

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00240

Pyrimidine metabolism

8 of 48

1.68

3.29

1.14e-10

map00230

Purine metabolism

6 of 81

1.33

1.58

9.34e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005971

Ribonucleoside-diphosphate reductase complex

2 of 3

2.28

0.82

0.0317

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0546

Nucleotide metabolism

2 of 6

1.98

0.77

0.0349

KW-0547

Nucleotide-binding

7 of 300

0.82

0.61

0.0041

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02867

Ribonucleotide reductase, barrel domain

2 of 2

2.46

0.79

0.0365

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