BN1708_000053 protein (Verticillium longisporum)

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Score

BN1708_000053

Glyco_trans_2-like domain-containing protein. (877 aa)

Predicted Functional Partners:

BN1708_003308

0.993

BN1708_017200

0.976

BN1708_017290

0.976

BN1708_006940

0.976

BN1708_013877

0.969

BN1708_012729

0.957

BN1708_007002

0.957

BN1708_008628

0.957

BN1708_008629

0.957

BN1708_011648

0.936

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_000053	BN1708_003308	A0A0G4KCG6	A0A0G4LDR0	Glyco_trans_2-like domain-containing protein.	ENDO3c domain-containing protein.	0.993
BN1708_000053	BN1708_006940	A0A0G4KCG6	A0A0G4MPC8	Glyco_trans_2-like domain-containing protein.	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.	0.976
BN1708_000053	BN1708_007002	A0A0G4KCG6	A0A0G4MPS2	Glyco_trans_2-like domain-containing protein.	Mannosyltransferase.	0.957
BN1708_000053	BN1708_008628	A0A0G4KCG6	A0A0G4N6E8	Glyco_trans_2-like domain-containing protein.	Mannosyltransferase.	0.957
BN1708_000053	BN1708_008629	A0A0G4KCG6	A0A0G4N6S1	Glyco_trans_2-like domain-containing protein.	Mannosyltransferase.	0.957
BN1708_000053	BN1708_011648	A0A0G4KCG6	A0A0G4L2Y6	Glyco_trans_2-like domain-containing protein.	Uncharacterized protein.	0.936
BN1708_000053	BN1708_012729	A0A0G4KCG6	A0A0G4LEF0	Glyco_trans_2-like domain-containing protein.	Mannosyltransferase.	0.957
BN1708_000053	BN1708_013877	A0A0G4KCG6	A0A0G4LQH2	Glyco_trans_2-like domain-containing protein.	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.	0.969
BN1708_000053	BN1708_017200	A0A0G4KCG6	A0A0G4KVQ1	Glyco_trans_2-like domain-containing protein.	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.	0.976
BN1708_000053	BN1708_017290	A0A0G4KCG6	A0A0G4KYV9	Glyco_trans_2-like domain-containing protein.	DAO domain-containing protein.	0.976
BN1708_003308	BN1708_000053	A0A0G4LDR0	A0A0G4KCG6	ENDO3c domain-containing protein.	Glyco_trans_2-like domain-containing protein.	0.993
BN1708_003308	BN1708_006940	A0A0G4LDR0	A0A0G4MPC8	ENDO3c domain-containing protein.	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.	0.983
BN1708_003308	BN1708_007002	A0A0G4LDR0	A0A0G4MPS2	ENDO3c domain-containing protein.	Mannosyltransferase.	0.559
BN1708_003308	BN1708_008628	A0A0G4LDR0	A0A0G4N6E8	ENDO3c domain-containing protein.	Mannosyltransferase.	0.960
BN1708_003308	BN1708_008629	A0A0G4LDR0	A0A0G4N6S1	ENDO3c domain-containing protein.	Mannosyltransferase.	0.960
BN1708_003308	BN1708_011648	A0A0G4LDR0	A0A0G4L2Y6	ENDO3c domain-containing protein.	Uncharacterized protein.	0.571
BN1708_003308	BN1708_012729	A0A0G4LDR0	A0A0G4LEF0	ENDO3c domain-containing protein.	Mannosyltransferase.	0.559
BN1708_003308	BN1708_013877	A0A0G4LDR0	A0A0G4LQH2	ENDO3c domain-containing protein.	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.	0.978
BN1708_003308	BN1708_017200	A0A0G4LDR0	A0A0G4KVQ1	ENDO3c domain-containing protein.	Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.	0.983
BN1708_003308	BN1708_017290	A0A0G4LDR0	A0A0G4KYV9	ENDO3c domain-containing protein.	DAO domain-containing protein.	0.983

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.842

expected number of edges:

10

PPI enrichment p-value:

2.73e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007265

Ras protein signal transduction

8 of 149

2.14

5.2

1.03e-12

GO:0007266

Rho protein signal transduction

3 of 54

2.15

1.51

0.0013

GO:1903975

Regulation of glial cell migration

2 of 9

2.75

1.24

0.0056

GO:0032535

Regulation of cellular component size

4 of 316

1.51

1.07

0.0041

GO:0008361

Regulation of cell size

3 of 151

1.71

0.9

0.0160

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003924

GTPase activity

8 of 391

1.72

3.25

6.50e-10

GO:0005525

GTP binding

8 of 603

1.53

2.52

9.87e-09

GO:0019003

GDP binding

3 of 51

2.18

1.96

0.00016

GO:0005096

GTPase activator activity

4 of 297

1.54

1.39

0.00054

GO:0035639

Purine ribonucleoside triphosphate binding

9 of 2557

0.95

1.0

5.95e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 6425

0.6

0.45

0.0043

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17135

Mixed, incl. Ras GTPase-activating protein, and Small GTPase, Ras-type

6 of 18

2.93

6.55

5.18e-13

CL:17157

Activation of RAS in B cells, and c-Kit-binding domain

3 of 5

3.19

3.0

3.58e-06

CL:17138

Core histone H2A/H2B/H3/H4, and Small GTPase, Ras-type

3 of 6

3.11

3.0

3.58e-06

CL:16875

Contains two conserved F residues, and Skeletal muscle satellite cell migration

3 of 5

3.19

3.0

3.58e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

onl04810

Regulation of actin cytoskeleton

8 of 252

1.91

4.49

1.27e-12

onl04137

Mitophagy - animal

5 of 73

2.24

4.07

3.62e-09

onl04625

C-type lectin receptor signaling pathway

5 of 131

1.99

3.29

4.58e-08

onl04010

MAPK signaling pathway

7 of 358

1.7

3.12

1.52e-09

onl04371

Apelin signaling pathway

5 of 160

1.9

3.04

9.70e-08

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8849471

PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

5 of 27

2.68

4.9

4.47e-10

MAP-9006927

Signaling by Non-Receptor Tyrosine Kinases

6 of 78

2.29

4.52

4.47e-10

MAP-8848021

Signaling by PTK6

6 of 78

2.29

4.52

4.47e-10

MAP-186763

Downstream signal transduction

4 of 39

2.42

3.29

4.29e-07

MAP-416550

Sema4D mediated inhibition of cell attachment and migration

3 of 10

2.89

3.09

2.11e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001489

Whole body

11 of 13816

0.31

0.28

0.0036

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0342

GTP-binding

5 of 198

1.81

2.42

2.74e-06

KW-0547

Nucleotide-binding

6 of 1222

1.1

1.0

0.00043

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00071

Ras family

3 of 24

2.5

1.89

0.00031

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020849

Small GTPase, Ras-type

4 of 12

2.93

3.89

6.98e-08

IPR001806

Small GTPase

6 of 117

2.12

3.63

1.70e-08

IPR005225

Small GTP-binding protein domain

4 of 141

1.86

1.63

0.00044

IPR045786

Rho GTPase-activating protein, pG1 and pG2 domain

2 of 2

3.41

1.6

0.0013

IPR039007

Rho GTPase-activating protein, pG1 domain

2 of 2

3.41

1.6

0.0013

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00173

Ras subfamily of RAS small GTPases

5 of 26

2.69

4.92

4.26e-10

SM00441

Contains two conserved F residues

3 of 5

3.19

3.31

9.98e-07

SM00324

GTPase-activator protein for Rho-like GTPases

3 of 91

1.93

1.41

0.0016

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