BN1708_011065 protein (Verticillium longisporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BN1708_011065

Uncharacterized protein. (493 aa)

Predicted Functional Partners:

BN1708_016870

0.992

BN1708_002959

0.992

BN1708_016743

0.951

BN1708_000152

0.926

BN1708_004745

0.926

BN1708_018229

0.873

BN1708_000030

0.872

BN1708_010494

0.865

BN1708_010723

0.865

BN1708_011353

0.865

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_000030	BN1708_002959	A0A0G4KCQ9	A0A0G4NRP2	Uncharacterized protein.	Uncharacterized protein.	0.870
BN1708_000030	BN1708_010494	A0A0G4KCQ9	A0A0G4KRV4	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.941
BN1708_000030	BN1708_010723	A0A0G4KCQ9	A0A0G4KTB1	Uncharacterized protein.	Uncharacterized protein.	0.949
BN1708_000030	BN1708_011065	A0A0G4KCQ9	A0A0G4KWF5	Uncharacterized protein.	Uncharacterized protein.	0.872
BN1708_000030	BN1708_011353	A0A0G4KCQ9	A0A0G4KZB9	Uncharacterized protein.	Uncharacterized protein.	0.941
BN1708_000030	BN1708_016743	A0A0G4KCQ9	A0A0G4N021	Uncharacterized protein.	Uncharacterized protein.	0.787
BN1708_000030	BN1708_016870	A0A0G4KCQ9	A0A0G4N4D5	Uncharacterized protein.	Uncharacterized protein.	0.870
BN1708_000152	BN1708_011065	A0A0G4KCC4	A0A0G4KWF5	Uncharacterized protein.	Uncharacterized protein.	0.926
BN1708_002959	BN1708_000030	A0A0G4NRP2	A0A0G4KCQ9	Uncharacterized protein.	Uncharacterized protein.	0.870
BN1708_002959	BN1708_010494	A0A0G4NRP2	A0A0G4KRV4	Uncharacterized protein.	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.890
BN1708_002959	BN1708_010723	A0A0G4NRP2	A0A0G4KTB1	Uncharacterized protein.	Uncharacterized protein.	0.865
BN1708_002959	BN1708_011065	A0A0G4NRP2	A0A0G4KWF5	Uncharacterized protein.	Uncharacterized protein.	0.992
BN1708_002959	BN1708_011353	A0A0G4NRP2	A0A0G4KZB9	Uncharacterized protein.	Uncharacterized protein.	0.890
BN1708_002959	BN1708_016743	A0A0G4NRP2	A0A0G4N021	Uncharacterized protein.	Uncharacterized protein.	0.691
BN1708_002959	BN1708_018229	A0A0G4NRP2	A0A0G4LWH2	Uncharacterized protein.	Uncharacterized protein.	0.870
BN1708_004745	BN1708_011065	A0A0G4NBD0	A0A0G4KWF5	Uncharacterized protein.	Uncharacterized protein.	0.926
BN1708_010494	BN1708_000030	A0A0G4KRV4	A0A0G4KCQ9	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.941
BN1708_010494	BN1708_002959	A0A0G4KRV4	A0A0G4NRP2	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.890
BN1708_010494	BN1708_011065	A0A0G4KRV4	A0A0G4KWF5	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.865
BN1708_010494	BN1708_011353	A0A0G4KRV4	A0A0G4KZB9	Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family.	Uncharacterized protein.	0.897

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.934

expected number of edges:

35

PPI enrichment p-value:

0.0106

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

6 of 207

1.19

1.14

0.00026

GO:0018106

Peptidyl-histidine phosphorylation

4 of 104

1.31

0.98

0.0037

GO:0050794

Regulation of cellular process

9 of 641

0.87

0.8

0.00013

GO:0050896

Response to stimulus

7 of 541

0.84

0.66

0.0019

GO:0006796

Phosphate-containing compound metabolic process

5 of 376

0.85

0.5

0.0311

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

5 of 109

1.39

1.23

0.00077

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3523

Mixed, incl. PAS-associated, C-terminal, and AAA ATPase domain

6 of 19

2.23

4.45

3.73e-10

CL:3520

PAS-associated, C-terminal, and GGDEF domain

7 of 30

2.1

4.44

8.77e-11

CL:3526

PAS-associated, C-terminal, and AAA ATPase domain

4 of 13

2.22

2.89

1.72e-06

CL:3527

PAS-associated, C-terminal, and AAA ATPase domain

3 of 7

2.36

2.23

5.66e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 575

0.92

0.96

4.76e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

5 of 110

1.39

1.43

0.00012

KW-0418

Kinase

6 of 161

1.3

1.42

4.12e-05

KW-0902

Two-component regulatory system

3 of 48

1.52

1.0

0.0067

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

6 of 72

1.65

2.17

3.67e-06

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 50

1.73

2.13

1.03e-05

IPR005467

Histidine kinase domain

6 of 80

1.6

2.1

3.67e-06

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 56

1.68

2.03

1.39e-05

IPR003594

Histidine kinase/HSP90-like ATPase

6 of 96

1.52

1.92

6.30e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

5 of 56

1.68

2.21

3.75e-06

SM00387

Histidine kinase-like ATPases

6 of 104

1.49

1.95

2.68e-06

SM00448

cheY-homologous receiver domain

5 of 101

1.42

1.59

4.10e-05

SM00073

Histidine Phosphotransfer domain

2 of 10

2.03

1.08

0.0087

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 18

1.77

0.87

0.0199

(more ...)

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