BN1708_000388 protein (Verticillium longisporum)

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Score

BN1708_000388

Nop domain-containing protein. (613 aa)

Predicted Functional Partners:

BN1708_002448

0.990

BN1708_005305

0.986

BN1708_007772

0.986

BN1708_002296

0.985

BN1708_017742

0.985

BN1708_009063

0.984

LSM3

0.984

BN1708_013769

0.984

BN1708_001002

0.984

BN1708_004732

0.982

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_000388	BN1708_001002	A0A0G4LC95	A0A0G4MH80	Nop domain-containing protein.	Uncharacterized protein.	0.984
BN1708_000388	BN1708_002296	A0A0G4LC95	A0A0G4KR09	Nop domain-containing protein.	Uncharacterized protein.	0.985
BN1708_000388	BN1708_002448	A0A0G4LC95	A0A0G4KTG6	Nop domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.990
BN1708_000388	BN1708_004732	A0A0G4LC95	A0A0G4M393	Nop domain-containing protein.	Uncharacterized protein.	0.982
BN1708_000388	BN1708_005305	A0A0G4LC95	A0A0G4M9B3	Nop domain-containing protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.986
BN1708_000388	BN1708_007772	A0A0G4LC95	A0A0G4NMT5	Nop domain-containing protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.986
BN1708_000388	BN1708_009063	A0A0G4LC95	A0A0G4KEY7	Nop domain-containing protein.	Sm domain-containing protein.	0.984
BN1708_000388	BN1708_013769	A0A0G4LC95	A0A0G4LNT9	Nop domain-containing protein.	Uncharacterized protein.	0.984
BN1708_000388	BN1708_017742	A0A0G4LC95	A0A0G4MHK1	Nop domain-containing protein.	PRP3 domain-containing protein.	0.985
BN1708_000388	LSM3	A0A0G4LC95	A0A0G4L0P6	Nop domain-containing protein.	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.984
BN1708_001002	BN1708_000388	A0A0G4MH80	A0A0G4LC95	Uncharacterized protein.	Nop domain-containing protein.	0.984
BN1708_001002	BN1708_002296	A0A0G4MH80	A0A0G4KR09	Uncharacterized protein.	Uncharacterized protein.	0.981
BN1708_001002	BN1708_002448	A0A0G4MH80	A0A0G4KTG6	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.984
BN1708_001002	BN1708_004732	A0A0G4MH80	A0A0G4M393	Uncharacterized protein.	Uncharacterized protein.	0.971
BN1708_001002	BN1708_005305	A0A0G4MH80	A0A0G4M9B3	Uncharacterized protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.972
BN1708_001002	BN1708_007772	A0A0G4MH80	A0A0G4NMT5	Uncharacterized protein.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.972
BN1708_001002	BN1708_009063	A0A0G4MH80	A0A0G4KEY7	Uncharacterized protein.	Sm domain-containing protein.	0.973
BN1708_001002	BN1708_017742	A0A0G4MH80	A0A0G4MHK1	Uncharacterized protein.	PRP3 domain-containing protein.	0.981
BN1708_001002	LSM3	A0A0G4MH80	A0A0G4L0P6	Uncharacterized protein.	U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.986
BN1708_002296	BN1708_000388	A0A0G4KR09	A0A0G4LC95	Uncharacterized protein.	Nop domain-containing protein.	0.985

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.934

expected number of edges:

35

PPI enrichment p-value:

0.0106

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000160

Phosphorelay signal transduction system

6 of 207

1.19

1.14

0.00026

GO:0018106

Peptidyl-histidine phosphorylation

4 of 104

1.31

0.98

0.0037

GO:0050794

Regulation of cellular process

9 of 641

0.87

0.8

0.00013

GO:0050896

Response to stimulus

7 of 541

0.84

0.66

0.0019

GO:0006796

Phosphate-containing compound metabolic process

5 of 376

0.85

0.5

0.0311

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000155

Phosphorelay sensor kinase activity

5 of 109

1.39

1.23

0.00077

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3523

Mixed, incl. PAS-associated, C-terminal, and AAA ATPase domain

6 of 19

2.23

4.45

3.73e-10

CL:3520

PAS-associated, C-terminal, and GGDEF domain

7 of 30

2.1

4.44

8.77e-11

CL:3526

PAS-associated, C-terminal, and AAA ATPase domain

4 of 13

2.22

2.89

1.72e-06

CL:3527

PAS-associated, C-terminal, and AAA ATPase domain

3 of 7

2.36

2.23

5.66e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 575

0.92

0.96

4.76e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

5 of 110

1.39

1.43

0.00012

KW-0418

Kinase

6 of 161

1.3

1.42

4.12e-05

KW-0902

Two-component regulatory system

3 of 48

1.52

1.0

0.0067

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

6 of 72

1.65

2.17

3.67e-06

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

5 of 50

1.73

2.13

1.03e-05

IPR005467

Histidine kinase domain

6 of 80

1.6

2.1

3.67e-06

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

5 of 56

1.68

2.03

1.39e-05

IPR003594

Histidine kinase/HSP90-like ATPase

6 of 96

1.52

1.92

6.30e-06

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

5 of 56

1.68

2.21

3.75e-06

SM00387

Histidine kinase-like ATPases

6 of 104

1.49

1.95

2.68e-06

SM00448

cheY-homologous receiver domain

5 of 101

1.42

1.59

4.10e-05

SM00073

Histidine Phosphotransfer domain

2 of 10

2.03

1.08

0.0087

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

2 of 18

1.77

0.87

0.0199

(more ...)

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