BN1708_012746 protein (Verticillium longisporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

BN1708_012746

Uncharacterized protein. (511 aa)

Predicted Functional Partners:

BN1708_016422

0.710

BN1708_020481

0.710

BN1708_009031

0.710

BN1708_019539

0.672

BN1708_013363

0.657

BN1708_013708

0.657

BN1708_007477

0.657

BN1708_005193

0.657

BN1708_017561

0.588

BN1708_012569

0.588

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_005193	BN1708_012569	A0A0G4MXF5	A0A0G4LBX6	Uncharacterized protein.	Uncharacterized protein.	0.932
BN1708_005193	BN1708_012746	A0A0G4MXF5	A0A0G4LDV7	Uncharacterized protein.	Uncharacterized protein.	0.657
BN1708_005193	BN1708_013363	A0A0G4MXF5	A0A0G4LJS7	Uncharacterized protein.	Uncharacterized protein.	0.435
BN1708_005193	BN1708_013708	A0A0G4MXF5	A0A0G4LNB5	Uncharacterized protein.	Uncharacterized protein.	0.452
BN1708_005193	BN1708_017561	A0A0G4MXF5	A0A0G4L5K7	Uncharacterized protein.	Uncharacterized protein.	0.932
BN1708_005193	BN1708_019539	A0A0G4MXF5	A0A0G4MJN5	Uncharacterized protein.	Uncharacterized protein.	0.770
BN1708_007477	BN1708_012746	A0A0G4MUN1	A0A0G4LDV7	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	Uncharacterized protein.	0.657
BN1708_009031	BN1708_012746	A0A0G4N6Z7	A0A0G4LDV7	MPN domain-containing protein.	Uncharacterized protein.	0.710
BN1708_009031	BN1708_016422	A0A0G4N6Z7	A0A0G4MLP9	MPN domain-containing protein.	MPN domain-containing protein.	0.543
BN1708_009031	BN1708_020481	A0A0G4N6Z7	A0A0G4MVX6	MPN domain-containing protein.	MPN domain-containing protein.	0.543
BN1708_012569	BN1708_005193	A0A0G4LBX6	A0A0G4MXF5	Uncharacterized protein.	Uncharacterized protein.	0.932
BN1708_012569	BN1708_012746	A0A0G4LBX6	A0A0G4LDV7	Uncharacterized protein.	Uncharacterized protein.	0.588
BN1708_012569	BN1708_013363	A0A0G4LBX6	A0A0G4LJS7	Uncharacterized protein.	Uncharacterized protein.	0.927
BN1708_012569	BN1708_013708	A0A0G4LBX6	A0A0G4LNB5	Uncharacterized protein.	Uncharacterized protein.	0.927
BN1708_012569	BN1708_019539	A0A0G4LBX6	A0A0G4MJN5	Uncharacterized protein.	Uncharacterized protein.	0.648
BN1708_012746	BN1708_005193	A0A0G4LDV7	A0A0G4MXF5	Uncharacterized protein.	Uncharacterized protein.	0.657
BN1708_012746	BN1708_007477	A0A0G4LDV7	A0A0G4MUN1	Uncharacterized protein.	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.	0.657
BN1708_012746	BN1708_009031	A0A0G4LDV7	A0A0G4N6Z7	Uncharacterized protein.	MPN domain-containing protein.	0.710
BN1708_012746	BN1708_012569	A0A0G4LDV7	A0A0G4LBX6	Uncharacterized protein.	Uncharacterized protein.	0.588
BN1708_012746	BN1708_013363	A0A0G4LDV7	A0A0G4LJS7	Uncharacterized protein.	Uncharacterized protein.	0.657

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.923

expected number of edges:

10

PPI enrichment p-value:

1.17e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010965

Regulation of mitotic sister chromatid separation

6 of 27

2.06

3.42

3.70e-08

GO:0033045

Regulation of sister chromatid segregation

6 of 30

2.01

3.35

3.70e-08

GO:0031145

Anaphase-promoting complex-dependent catabolic process

4 of 13

2.2

2.53

1.01e-05

GO:0030071

Regulation of mitotic metaphase/anaphase transition

4 of 25

1.91

2.05

4.99e-05

GO:0007094

Mitotic spindle assembly checkpoint signaling

3 of 16

1.98

1.58

0.00075

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019003

GDP binding

2 of 3

2.53

0.73

0.0467

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005680

Anaphase-promoting complex

5 of 15

2.23

3.41

1.17e-07

GO:0140535

Intracellular protein-containing complex

6 of 382

0.91

0.66

0.0055

GO:0140513

Nuclear protein-containing complex

6 of 580

0.72

0.42

0.0402

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2016

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

8 of 22

2.27

6.05

3.99e-14

CL:2017

Anaphase-promoting complex, and APC-Cdc20 mediated degradation of Nek2A

6 of 17

2.26

4.65

1.56e-10

CL:2021

Anaphase-promoting complex-dependent catabolic process

5 of 11

2.37

4.13

5.57e-09

CL:2025

Anaphase-promoting complex-dependent catabolic process

3 of 6

2.41

2.26

5.43e-05

CL:2050

Mitotic checkpoint complex, and Mad3/Bub1 homology region 1

2 of 5

2.31

1.14

0.0077

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

10 of 106

1.68

3.99

1.40e-14

map04111

Cell cycle - yeast

8 of 108

1.58

2.92

2.79e-10

map04120

Ubiquitin mediated proteolysis

5 of 85

1.48

1.74

1.88e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

3 of 8

2.28

1.88

0.00027

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

3 of 8

2.28

1.88

0.00027

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

3 of 13

2.07

1.7

0.00048

MAP-453276

Regulation of mitotic cell cycle

3 of 17

1.96

1.56

0.00079

MAP-174143

APC/C-mediated degradation of cell cycle proteins

3 of 17

1.96

1.56

0.00079

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005680

Anaphase-promoting complex

4 of 10

2.31

2.66

7.05e-06

GOCC:0033597

Mitotic checkpoint complex

3 of 4

2.58

2.28

5.83e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12895

Anaphase-promoting complex, cyclosome, subunit 3

2 of 2

2.71

0.98

0.0166

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00777

Mad3/BUB1 hoMad3/BUB1 homology region 1

2 of 2

2.71

1.22

0.0061

SM00173

Ras subfamily of RAS small GTPases

2 of 4

2.41

1.15

0.0076

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