BN1708_019148 protein (Verticillium longisporum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BN1708_019148

Uncharacterized protein. (150 aa)

Predicted Functional Partners:

BN1708_001214

0.999

BN1708_001217

0.999

BN1708_002300

0.987

BN1708_010503

0.985

BN1708_014009

0.985

BN1708_002310

0.980

BN1708_002315

0.980

BN1708_018686

0.980

BN1708_012549

0.979

BN1708_006402

0.956

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_001214	BN1708_001217	A0A0G4MMN4	A0A0G4MMW4	3'-5' exonuclease domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.986
BN1708_001214	BN1708_002300	A0A0G4MMN4	A0A0G4KQ49	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.998
BN1708_001214	BN1708_010503	A0A0G4MMN4	A0A0G4KRK0	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.498
BN1708_001214	BN1708_012549	A0A0G4MMN4	A0A0G4LB74	3'-5' exonuclease domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.999
BN1708_001214	BN1708_014009	A0A0G4MMN4	A0A0G4LR26	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.498
BN1708_001214	BN1708_019148	A0A0G4MMN4	A0A0G4MFY9	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.999
BN1708_001217	BN1708_001214	A0A0G4MMW4	A0A0G4MMN4	3'-5' exonuclease domain-containing protein.	3'-5' exonuclease domain-containing protein.	0.986
BN1708_001217	BN1708_002300	A0A0G4MMW4	A0A0G4KQ49	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.998
BN1708_001217	BN1708_010503	A0A0G4MMW4	A0A0G4KRK0	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.498
BN1708_001217	BN1708_012549	A0A0G4MMW4	A0A0G4LB74	3'-5' exonuclease domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.999
BN1708_001217	BN1708_014009	A0A0G4MMW4	A0A0G4LR26	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.498
BN1708_001217	BN1708_019148	A0A0G4MMW4	A0A0G4MFY9	3'-5' exonuclease domain-containing protein.	Uncharacterized protein.	0.999
BN1708_002300	BN1708_001214	A0A0G4KQ49	A0A0G4MMN4	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.998
BN1708_002300	BN1708_001217	A0A0G4KQ49	A0A0G4MMW4	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.998
BN1708_002300	BN1708_002310	A0A0G4KQ49	A0A0G4KR22	Uncharacterized protein.	PH_TFIIH domain-containing protein.	0.995
BN1708_002300	BN1708_002315	A0A0G4KQ49	A0A0G4KR27	Uncharacterized protein.	BSD domain-containing protein.	0.995
BN1708_002300	BN1708_006402	A0A0G4KQ49	A0A0G4MK96	Uncharacterized protein.	C2H2-type domain-containing protein.	0.998
BN1708_002300	BN1708_010503	A0A0G4KQ49	A0A0G4KRK0	Uncharacterized protein.	Uncharacterized protein.	0.998
BN1708_002300	BN1708_012549	A0A0G4KQ49	A0A0G4LB74	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.983
BN1708_002300	BN1708_014009	A0A0G4KQ49	A0A0G4LR26	Uncharacterized protein.	Uncharacterized protein.	0.998

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.72

expected number of edges:

11

PPI enrichment p-value:

2.98e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042273

Ribosomal large subunit biogenesis

7 of 58

2.06

4.23

2.26e-10

GO:0000054

Ribosomal subunit export from nucleus

4 of 16

2.38

2.97

1.79e-06

GO:0042254

Ribosome biogenesis

9 of 241

1.55

2.86

2.26e-10

GO:0042255

Ribosome assembly

4 of 32

2.08

2.4

1.35e-05

GO:0000027

Ribosomal large subunit assembly

3 of 16

2.26

1.98

0.00016

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043023

Ribosomal large subunit binding

2 of 7

2.44

0.74

0.0451

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030687

Preribosome, large subunit precursor

3 of 23

2.1

1.6

0.00079

GO:0005730

Nucleolus

5 of 197

1.39

1.23

0.00075

GO:1990904

Ribonucleoprotein complex

4 of 350

1.04

0.61

0.0241

GO:0043232

Intracellular non-membrane-bounded organelle

6 of 862

0.83

0.55

0.0119

GO:0005634

Nucleus

8 of 1734

0.65

0.45

0.0101

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4429

Ribosomal large subunit biogenesis, and Nucleolar protein,Nop52

10 of 44

2.34

8.3

7.20e-20

CL:4433

Ribosomal large subunit biogenesis, and GTP-binding protein, orthogonal bundle domain superfamily

6 of 32

2.26

4.75

8.55e-11

CL:4483

Mixed, incl. Ribosomal protein S8e, and Ribosomal protein L24e

3 of 5

2.76

2.87

5.13e-06

CL:4442

Ribosome biogenesis

2 of 5

2.58

1.46

0.0021

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

6 of 69

1.92

3.46

6.58e-09

map03010

Ribosome

3 of 153

1.27

0.65

0.0336

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005730

Nucleolus

3 of 86

1.53

0.68

0.0406

GOCC:0043232

Intracellular non-membrane-bounded organelle

6 of 758

0.88

0.49

0.0406

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0690

Ribosome biogenesis

3 of 17

2.23

1.92

0.00021

KW-0539

Nucleus

5 of 285

1.23

1.09

0.00069

KW-0963

Cytoplasm

3 of 137

1.32

0.71

0.0262

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01926

50S ribosome-binding GTPase

3 of 19

2.18

1.55

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006073

GTP binding domain

3 of 13

2.35

1.58

0.0011

IPR030378

Circularly permuted (CP)-type guanine nucleotide-binding (G) domain

2 of 4

2.68

0.96

0.0179

IPR022755

Zinc finger, double-stranded RNA binding

2 of 7

2.44

0.85

0.0286

IPR003604

Matrin/U1-C-like, C2H2-type zinc finger

2 of 8

2.38

0.84

0.0286

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