BN1708_007420 protein (Verticillium longisporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

BN1708_007420

Uncharacterized protein. (587 aa)

Predicted Functional Partners:

BN1708_015871

0.596

BN1708_015874

0.596

BN1708_007103

0.561

BN1708_016576

0.561

BN1708_014270

0.559

BN1708_009855

0.548

BN1708_013387

0.548

BN1708_003906

0.548

BN1708_020182

0.548

BN1708_009487

0.499

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_003906	BN1708_007420	A0A0G4LS15	A0A0G4MMX6	DOC domain-containing protein.	Uncharacterized protein.	0.548
BN1708_003906	BN1708_014270	A0A0G4LS15	A0A0G4LUK7	DOC domain-containing protein.	GMC_OxRdtase_N domain-containing protein.	0.548
BN1708_007103	BN1708_007420	A0A0G4MQS8	A0A0G4MMX6	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.561
BN1708_007103	BN1708_014270	A0A0G4MQS8	A0A0G4LUK7	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	GMC_OxRdtase_N domain-containing protein.	0.859
BN1708_007103	BN1708_015871	A0A0G4MQS8	A0A0G4M9E8	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.924
BN1708_007103	BN1708_015874	A0A0G4MQS8	A0A0G4MAE5	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.924
BN1708_007420	BN1708_003906	A0A0G4MMX6	A0A0G4LS15	Uncharacterized protein.	DOC domain-containing protein.	0.548
BN1708_007420	BN1708_007103	A0A0G4MMX6	A0A0G4MQS8	Uncharacterized protein.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.561
BN1708_007420	BN1708_009487	A0A0G4MMX6	A0A0G4KHS1	Uncharacterized protein.	SGL domain-containing protein.	0.499
BN1708_007420	BN1708_009855	A0A0G4MMX6	A0A0G4KL02	Uncharacterized protein.	Aldedh domain-containing protein.	0.548
BN1708_007420	BN1708_013387	A0A0G4MMX6	A0A0G4LK05	Uncharacterized protein.	Uncharacterized protein; Belongs to the aldehyde dehydrogenase family.	0.548
BN1708_007420	BN1708_014270	A0A0G4MMX6	A0A0G4LUK7	Uncharacterized protein.	GMC_OxRdtase_N domain-containing protein.	0.559
BN1708_007420	BN1708_015871	A0A0G4MMX6	A0A0G4M9E8	Uncharacterized protein.	Uncharacterized protein.	0.596
BN1708_007420	BN1708_015874	A0A0G4MMX6	A0A0G4MAE5	Uncharacterized protein.	Uncharacterized protein.	0.596
BN1708_007420	BN1708_016576	A0A0G4MMX6	A0A0G4MSM4	Uncharacterized protein.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.561
BN1708_007420	BN1708_020182	A0A0G4MMX6	A0A0G4MS22	Uncharacterized protein.	Aldedh domain-containing protein.	0.548
BN1708_009487	BN1708_007420	A0A0G4KHS1	A0A0G4MMX6	SGL domain-containing protein.	Uncharacterized protein.	0.499
BN1708_009487	BN1708_014270	A0A0G4KHS1	A0A0G4LUK7	SGL domain-containing protein.	GMC_OxRdtase_N domain-containing protein.	0.499
BN1708_009855	BN1708_007420	A0A0G4KL02	A0A0G4MMX6	Aldedh domain-containing protein.	Uncharacterized protein.	0.548
BN1708_009855	BN1708_014270	A0A0G4KL02	A0A0G4LUK7	Aldedh domain-containing protein.	GMC_OxRdtase_N domain-containing protein.	0.866

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.913

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032981

Mitochondrial respiratory chain complex I assembly

6 of 18

2.6

5.4

3.12e-11

GO:0015990

Electron transport coupled proton transport

2 of 2

3.08

1.58

0.0014

GO:0022607

Cellular component assembly

7 of 557

1.18

1.24

5.29e-05

GO:1902600

Proton transmembrane transport

3 of 120

1.48

0.74

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 25

2.28

2.57

1.02e-05

GO:0015399

Primary active transmembrane transporter activity

5 of 146

1.61

1.91

1.91e-05

GO:0048038

Quinone binding

2 of 10

2.38

1.2

0.0062

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

5 of 59

2.01

2.94

4.40e-07

GO:0005747

Mitochondrial respiratory chain complex I

4 of 25

2.28

2.93

1.74e-06

GO:0098798

Mitochondrial protein-containing complex

5 of 195

1.49

1.72

2.52e-05

GO:0005743

Mitochondrial inner membrane

5 of 272

1.34

1.39

0.00011

GO:0005739

Mitochondrion

10 of 1039

1.06

1.31

8.48e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10257

Respirasome, and NAD(P)H-binding

9 of 91

2.07

5.68

6.58e-15

CL:10427

NADH dehydrogenase complex assembly

4 of 6

2.9

4.4

7.21e-09

CL:10281

Complex I biogenesis

5 of 29

2.31

4.08

5.37e-09

CL:10284

Complex I biogenesis

4 of 24

2.3

3.18

5.29e-07

CL:10287

NADH dehydrogenase complex

3 of 17

2.32

2.27

4.46e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

6 of 148

1.69

2.6

1.56e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

8 of 34

2.45

7.16

8.18e-16

MAP-611105

Respiratory electron transport

8 of 68

2.15

5.63

6.49e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 82

2.07

5.24

1.77e-13

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 173

1.74

3.59

4.11e-11

MAP-1430728

Metabolism

9 of 2359

0.66

0.52

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

8 of 810

1.07

1.12

3.00e-05

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3298

0.56

0.42

0.0042

GOCC:0005737

Cytoplasm

10 of 3536

0.53

0.4

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

3 of 41

1.94

1.44

0.0014

KW-0004

4Fe-4S

2 of 12

2.3

1.16

0.0071

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01058

NADH ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.32

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006138

NADH-ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.08

0.0115

IPR006137

NADH:ubiquinone oxidoreductase-like, 20kDa subunit

2 of 2

3.08

1.08

0.0115

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