BN1708_016521 protein (Verticillium longisporum)

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query proteins and first shell of interactors

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

BN1708_016521

Uncharacterized protein. (166 aa)

Predicted Functional Partners:

PAC1

0.797

BN1708_003151

0.797

BN1708_015085

0.797

BN1708_015877

0.797

PAC1-2

0.797

BN1708_012133

0.522

BN1708_000777

0.522

BN1708_000887

0.522

BN1708_008786

0.522

BN1708_001938

0.477

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_000777	BN1708_016521	A0A0G4LYB8	A0A0G4MQB2	Uncharacterized protein.	Uncharacterized protein.	0.522
BN1708_000887	BN1708_016521	A0A0G4M8U2	A0A0G4MQB2	PlsC domain-containing protein.	Uncharacterized protein.	0.522
BN1708_001938	BN1708_016521	A0A0G4KCZ7	A0A0G4MQB2	Uncharacterized protein.	Uncharacterized protein.	0.477
BN1708_003151	BN1708_016521	A0A0G4L8S0	A0A0G4MQB2	Amino_oxidase domain-containing protein.	Uncharacterized protein.	0.797
BN1708_008786	BN1708_016521	A0A0G4N868	A0A0G4MQB2	PlsC domain-containing protein.	Uncharacterized protein.	0.522
BN1708_012133	BN1708_016521	A0A0G4L7C5	A0A0G4MQB2	Acyltransf_C domain-containing protein.	Uncharacterized protein.	0.522
BN1708_015085	BN1708_016521	A0A0G4M1A8	A0A0G4MQB2	Amino_oxidase domain-containing protein.	Uncharacterized protein.	0.797
BN1708_015877	BN1708_016521	A0A0G4M9F9	A0A0G4MQB2	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.797
BN1708_016521	BN1708_000777	A0A0G4MQB2	A0A0G4LYB8	Uncharacterized protein.	Uncharacterized protein.	0.522
BN1708_016521	BN1708_000887	A0A0G4MQB2	A0A0G4M8U2	Uncharacterized protein.	PlsC domain-containing protein.	0.522
BN1708_016521	BN1708_001938	A0A0G4MQB2	A0A0G4KCZ7	Uncharacterized protein.	Uncharacterized protein.	0.477
BN1708_016521	BN1708_003151	A0A0G4MQB2	A0A0G4L8S0	Uncharacterized protein.	Amino_oxidase domain-containing protein.	0.797
BN1708_016521	BN1708_008786	A0A0G4MQB2	A0A0G4N868	Uncharacterized protein.	PlsC domain-containing protein.	0.522
BN1708_016521	BN1708_012133	A0A0G4MQB2	A0A0G4L7C5	Uncharacterized protein.	Acyltransf_C domain-containing protein.	0.522
BN1708_016521	BN1708_015085	A0A0G4MQB2	A0A0G4M1A8	Uncharacterized protein.	Amino_oxidase domain-containing protein.	0.797
BN1708_016521	BN1708_015877	A0A0G4MQB2	A0A0G4M9F9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.797
BN1708_016521	PAC1	A0A0G4MQB2	A0A0G4KKK1	Uncharacterized protein.	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.	0.797
BN1708_016521	PAC1-2	A0A0G4MQB2	A0A0G4MV47	Uncharacterized protein.	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.	0.797
PAC1	BN1708_016521	A0A0G4KKK1	A0A0G4MQB2	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.	Uncharacterized protein.	0.797
PAC1-2	BN1708_016521	A0A0G4MV47	A0A0G4MQB2	Nuclear distribution protein PAC1; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.	Uncharacterized protein.	0.797

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.933

expected number of edges:

18

PPI enrichment p-value:

6.73e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009116

Nucleoside metabolic process

3 of 10

2.01

1.31

0.0029

GO:0002100

tRNA wobble adenosine to inosine editing

2 of 2

2.54

1.1

0.0098

GO:0043094

Cellular metabolic compound salvage

2 of 6

2.06

0.89

0.0209

GO:0008295

Spermidine biosynthetic process

2 of 6

2.06

0.89

0.0209

GO:0055086

Nucleobase-containing small molecule metabolic process

4 of 117

1.07

0.64

0.0209

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019239

Deaminase activity

3 of 5

2.31

1.71

0.00059

GO:0016814

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines

3 of 8

2.11

1.58

0.00087

GO:0052717

tRNA-specific adenosine-34 deaminase activity

2 of 2

2.54

1.19

0.0067

GO:0016810

Hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

4 of 53

1.41

1.08

0.0027

GO:0004766

Spermidine synthase activity

2 of 5

2.14

1.0

0.0134

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1418

Mixed, incl. Nucleoside metabolic process, and Deaminase activity

7 of 10

2.38

5.62

2.13e-12

CL:1421

Nucleoside metabolic process, and Deaminase activity

4 of 5

2.44

3.2

7.13e-07

CL:1154

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

9 of 142

1.34

2.08

2.86e-09

CL:1328

Polyamine metabolic process

2 of 6

2.06

0.84

0.0262

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00330

Arginine and proline metabolism

3 of 25

1.61

1.16

0.0032

map00270

Cysteine and methionine metabolism

3 of 33

1.49

1.05

0.0046

map00480

Glutathione metabolism

2 of 16

1.63

0.75

0.0318

map00230

Purine metabolism

3 of 82

1.1

0.59

0.0351

map01100

Metabolic pathways

11 of 1094

0.54

0.46

0.00014

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0378

Hydrolase

6 of 247

0.92

0.67

0.0057

KW-0862

Zinc

3 of 52

1.3

0.62

0.0430

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