BN1708_007380 protein (Verticillium longisporum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

BN1708_007380

Uncharacterized protein. (442 aa)

Predicted Functional Partners:

BN1708_009397

0.734

BN1708_013314

0.734

BN1708_014926

0.734

BN1708_015707

0.734

BN1708_007024

0.734

BN1708_002096

0.472

BN1708_016737

0.472

BN1708_009868

0.450

BN1708_009861

0.450

BN1708_019653

0.437

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_002096	BN1708_007024	A0A0G4KIB8	A0A0G4MQJ4	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.481
BN1708_002096	BN1708_007380	A0A0G4KIB8	A0A0G4MTA7	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.472
BN1708_002096	BN1708_009397	A0A0G4KIB8	A0A0G4KGF2	Glyceraldehyde-3-phosphate dehydrogenase.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.481
BN1708_002096	BN1708_009861	A0A0G4KIB8	A0A0G4LSI8	Glyceraldehyde-3-phosphate dehydrogenase.	Cytochrome b5 heme-binding domain-containing protein.	0.453
BN1708_002096	BN1708_009868	A0A0G4KIB8	A0A0G4KMR4	Glyceraldehyde-3-phosphate dehydrogenase.	Cytochrome b5 heme-binding domain-containing protein.	0.453
BN1708_002096	BN1708_013314	A0A0G4KIB8	A0A0G4LJP5	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.481
BN1708_002096	BN1708_014926	A0A0G4KIB8	A0A0G4M0B5	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.481
BN1708_002096	BN1708_015707	A0A0G4KIB8	A0A0G4M7K7	Glyceraldehyde-3-phosphate dehydrogenase.	Uncharacterized protein.	0.481
BN1708_002096	BN1708_019653	A0A0G4KIB8	A0A0G4MKW2	Glyceraldehyde-3-phosphate dehydrogenase.	Thymidylat_synt domain-containing protein.	0.540
BN1708_007024	BN1708_002096	A0A0G4MQJ4	A0A0G4KIB8	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.481
BN1708_007024	BN1708_007380	A0A0G4MQJ4	A0A0G4MTA7	Uncharacterized protein.	Uncharacterized protein.	0.734
BN1708_007024	BN1708_009397	A0A0G4MQJ4	A0A0G4KGF2	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.982
BN1708_007024	BN1708_009861	A0A0G4MQJ4	A0A0G4LSI8	Uncharacterized protein.	Cytochrome b5 heme-binding domain-containing protein.	0.969
BN1708_007024	BN1708_009868	A0A0G4MQJ4	A0A0G4KMR4	Uncharacterized protein.	Cytochrome b5 heme-binding domain-containing protein.	0.969
BN1708_007024	BN1708_013314	A0A0G4MQJ4	A0A0G4LJP5	Uncharacterized protein.	Uncharacterized protein.	0.981
BN1708_007024	BN1708_014926	A0A0G4MQJ4	A0A0G4M0B5	Uncharacterized protein.	Uncharacterized protein.	0.981
BN1708_007024	BN1708_015707	A0A0G4MQJ4	A0A0G4M7K7	Uncharacterized protein.	Uncharacterized protein.	0.981
BN1708_007024	BN1708_016737	A0A0G4MQJ4	A0A0G4M1Y4	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.481
BN1708_007024	BN1708_019653	A0A0G4MQJ4	A0A0G4MKW2	Uncharacterized protein.	Thymidylat_synt domain-containing protein.	0.403
BN1708_007380	BN1708_002096	A0A0G4MTA7	A0A0G4KIB8	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase.	0.472

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.83

expected number of edges:

11

PPI enrichment p-value:

1.01e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042127

Regulation of cell population proliferation

3 of 32

2.16

1.29

0.0036

GO:0033674

Positive regulation of kinase activity

3 of 79

1.76

0.99

0.0106

GO:0007167

Enzyme-linked receptor protein signaling pathway

3 of 81

1.75

0.99

0.0106

GO:0048731

System development

3 of 101

1.66

0.96

0.0106

GO:0051247

Positive regulation of protein metabolic process

3 of 110

1.62

0.95

0.0106

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004713

Protein tyrosine kinase activity

4 of 127

1.68

1.31

0.0016

GO:0052866

Phosphatidylinositol phosphate phosphatase activity

2 of 28

2.04

0.78

0.0354

GO:0004714

Transmembrane receptor protein tyrosine kinase activity

2 of 37

1.92

0.71

0.0467

GO:0004672

Protein kinase activity

5 of 597

1.11

0.68

0.0163

GO:0140096

Catalytic activity, acting on a protein

6 of 1429

0.81

0.47

0.0354

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009925

Basal plasma membrane

2 of 3

3.01

1.4

0.0030

GO:0043235

Receptor complex

2 of 30

2.01

0.72

0.0458

GO:0071944

Cell periphery

5 of 929

0.92

0.49

0.0458

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:675

Mixed, incl. Phosphotyrosine residue binding, and Transmembrane receptor protein kinase activity

4 of 37

2.22

2.41

1.87e-05

CL:688

Mixed, incl. Phosphotyrosine residue binding, and Basal plasma membrane

3 of 13

2.55

2.41

3.13e-05

CL:1879

Mixed, incl. Roc domain, and GDP metabolic process

2 of 5

2.79

1.63

0.0011

CL:1697

Mixed, incl. Integrin alpha beta-propellor, and ECM proteoglycans

2 of 7

2.64

1.5

0.0018

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9006934

Signaling by Receptor Tyrosine Kinases

4 of 138

1.65

1.3

0.0015

MAP-9006927

Signaling by Non-Receptor Tyrosine Kinases

2 of 31

2.0

0.74

0.0403

MAP-8848021

Signaling by PTK6

2 of 31

2.0

0.74

0.0403

MAP-6811558

PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling

2 of 42

1.86

0.72

0.0435

MAP-5684996

MAPK1/MAPK3 signaling

3 of 135

1.53

0.69

0.0403

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001245

Serine-threonine/tyrosine-protein kinase, catalytic domain

5 of 442

1.24

0.73

0.0188

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