BN1708_007833 protein (Verticillium longisporum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BN1708_007833

Uncharacterized protein. (219 aa)

Predicted Functional Partners:

BN1708_012485

0.999

BN1708_015474

0.997

BN1708_004955

0.997

BN1708_006205

0.996

BN1708_006208

0.996

BN1708_016495

0.996

BN1708_017595

0.990

BN1708_006034

0.990

BN1708_009366

0.986

BN1708_018247

0.986

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_004955	BN1708_006034	A0A0G4N9Q9	A0A0G4MHM2	Uncharacterized protein.	Uncharacterized protein.	0.990
BN1708_004955	BN1708_006205	A0A0G4N9Q9	A0A0G4MI34	Uncharacterized protein.	Uncharacterized protein.	0.996
BN1708_004955	BN1708_006208	A0A0G4N9Q9	A0A0G4MIA1	Uncharacterized protein.	Uncharacterized protein.	0.996
BN1708_004955	BN1708_007833	A0A0G4N9Q9	A0A0G4MWA2	Uncharacterized protein.	Uncharacterized protein.	0.997
BN1708_004955	BN1708_009366	A0A0G4N9Q9	A0A0G4KGQ6	Uncharacterized protein.	Uncharacterized protein.	0.985
BN1708_004955	BN1708_012485	A0A0G4N9Q9	A0A0G4LB99	Uncharacterized protein.	Uncharacterized protein.	0.999
BN1708_004955	BN1708_016495	A0A0G4N9Q9	A0A0G4MP37	Uncharacterized protein.	Uncharacterized protein.	0.996
BN1708_004955	BN1708_017595	A0A0G4N9Q9	A0A0G4L6C6	Uncharacterized protein.	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	0.990
BN1708_004955	BN1708_018247	A0A0G4N9Q9	A0A0G4LX52	Uncharacterized protein.	Uncharacterized protein.	0.985
BN1708_006034	BN1708_004955	A0A0G4MHM2	A0A0G4N9Q9	Uncharacterized protein.	Uncharacterized protein.	0.990
BN1708_006034	BN1708_006205	A0A0G4MHM2	A0A0G4MI34	Uncharacterized protein.	Uncharacterized protein.	0.985
BN1708_006034	BN1708_006208	A0A0G4MHM2	A0A0G4MIA1	Uncharacterized protein.	Uncharacterized protein.	0.985
BN1708_006034	BN1708_007833	A0A0G4MHM2	A0A0G4MWA2	Uncharacterized protein.	Uncharacterized protein.	0.990
BN1708_006034	BN1708_012485	A0A0G4MHM2	A0A0G4LB99	Uncharacterized protein.	Uncharacterized protein.	0.994
BN1708_006034	BN1708_015474	A0A0G4MHM2	A0A0G4M4B4	Uncharacterized protein.	Uncharacterized protein.	0.990
BN1708_006034	BN1708_016495	A0A0G4MHM2	A0A0G4MP37	Uncharacterized protein.	Uncharacterized protein.	0.985
BN1708_006205	BN1708_004955	A0A0G4MI34	A0A0G4N9Q9	Uncharacterized protein.	Uncharacterized protein.	0.996
BN1708_006205	BN1708_006034	A0A0G4MI34	A0A0G4MHM2	Uncharacterized protein.	Uncharacterized protein.	0.985
BN1708_006205	BN1708_007833	A0A0G4MI34	A0A0G4MWA2	Uncharacterized protein.	Uncharacterized protein.	0.996
BN1708_006205	BN1708_009366	A0A0G4MI34	A0A0G4KGQ6	Uncharacterized protein.	Uncharacterized protein.	0.977

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.913

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032981

Mitochondrial respiratory chain complex I assembly

6 of 18

2.6

5.4

3.12e-11

GO:0015990

Electron transport coupled proton transport

2 of 2

3.08

1.58

0.0014

GO:0022607

Cellular component assembly

7 of 557

1.18

1.24

5.29e-05

GO:1902600

Proton transmembrane transport

3 of 120

1.48

0.74

0.0287

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

4 of 25

2.28

2.57

1.02e-05

GO:0015399

Primary active transmembrane transporter activity

5 of 146

1.61

1.91

1.91e-05

GO:0048038

Quinone binding

2 of 10

2.38

1.2

0.0062

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070469

Respirasome

5 of 59

2.01

2.94

4.40e-07

GO:0005747

Mitochondrial respiratory chain complex I

4 of 25

2.28

2.93

1.74e-06

GO:0098798

Mitochondrial protein-containing complex

5 of 195

1.49

1.72

2.52e-05

GO:0005743

Mitochondrial inner membrane

5 of 272

1.34

1.39

0.00011

GO:0005739

Mitochondrion

10 of 1039

1.06

1.31

8.48e-08

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10257

Respirasome, and NAD(P)H-binding

9 of 91

2.07

5.68

6.58e-15

CL:10427

NADH dehydrogenase complex assembly

4 of 6

2.9

4.4

7.21e-09

CL:10281

Complex I biogenesis

5 of 29

2.31

4.08

5.37e-09

CL:10284

Complex I biogenesis

4 of 24

2.3

3.18

5.29e-07

CL:10287

NADH dehydrogenase complex

3 of 17

2.32

2.27

4.46e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

6 of 148

1.69

2.6

1.56e-07

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

8 of 34

2.45

7.16

8.18e-16

MAP-611105

Respiratory electron transport

8 of 68

2.15

5.63

6.49e-14

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

8 of 82

2.07

5.24

1.77e-13

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

8 of 173

1.74

3.59

4.11e-11

MAP-1430728

Metabolism

9 of 2359

0.66

0.52

0.0014

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005739

Mitochondrion

8 of 810

1.07

1.12

3.00e-05

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3298

0.56

0.42

0.0042

GOCC:0005737

Cytoplasm

10 of 3536

0.53

0.4

0.0055

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

3 of 41

1.94

1.44

0.0014

KW-0004

4Fe-4S

2 of 12

2.3

1.16

0.0071

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01058

NADH ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.32

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006138

NADH-ubiquinone oxidoreductase, 20 Kd subunit

2 of 2

3.08

1.08

0.0115

IPR006137

NADH:ubiquinone oxidoreductase-like, 20kDa subunit

2 of 2

3.08

1.08

0.0115

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