BN1708_008315 protein (Verticillium longisporum)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

BN1708_008315

Uncharacterized protein. (233 aa)

Predicted Functional Partners:

BN1708_012334

0.531

BN1708_010146

0.527

BN1708_009111

0.485

BN1708_014076

0.485

BN1708_001198

0.485

BN1708_016634

0.485

BN1708_007819

0.485

BN1708_010352

0.466

BN1708_017209

0.466

BN1708_011920

0.452

Your Current Organism:

Verticillium longisporum

NCBI taxonomy Id: 100787
Other names: CBS 124.64, CBS H-19247, MUCL 9802, NRRL 54793, PD687, V. longisporum, Verticillium dahliae var. longisporum, Verticillium longisporum (C. Stark) Karapapa et al.

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... functional annotations:

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BN1708_001198	BN1708_008315	A0A0G4MN33	A0A0G4N313	USP domain-containing protein.	Uncharacterized protein.	0.485
BN1708_007819	BN1708_008315	A0A0G4MW99	A0A0G4N313	USP domain-containing protein; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.485
BN1708_008315	BN1708_001198	A0A0G4N313	A0A0G4MN33	Uncharacterized protein.	USP domain-containing protein.	0.485
BN1708_008315	BN1708_007819	A0A0G4N313	A0A0G4MW99	Uncharacterized protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.485
BN1708_008315	BN1708_009111	A0A0G4N313	A0A0G4KED7	Uncharacterized protein.	USP domain-containing protein.	0.485
BN1708_008315	BN1708_010146	A0A0G4N313	A0A0G4NC36	Uncharacterized protein.	Uncharacterized protein.	0.527
BN1708_008315	BN1708_010352	A0A0G4N313	A0A0G4KRR3	Uncharacterized protein.	RING-type domain-containing protein.	0.466
BN1708_008315	BN1708_011920	A0A0G4N313	A0A0G4L4X8	Uncharacterized protein.	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	0.452
BN1708_008315	BN1708_012334	A0A0G4N313	A0A0G4L900	Uncharacterized protein.	Uncharacterized protein.	0.531
BN1708_008315	BN1708_014076	A0A0G4N313	A0A0G4LS80	Uncharacterized protein.	USP domain-containing protein; Belongs to the peptidase C19 family.	0.485
BN1708_008315	BN1708_016634	A0A0G4N313	A0A0G4MVP2	Uncharacterized protein.	USP domain-containing protein.	0.485
BN1708_008315	BN1708_017209	A0A0G4N313	A0A0G4KVZ9	Uncharacterized protein.	RING-type domain-containing protein.	0.466
BN1708_009111	BN1708_008315	A0A0G4KED7	A0A0G4N313	USP domain-containing protein.	Uncharacterized protein.	0.485
BN1708_010146	BN1708_008315	A0A0G4NC36	A0A0G4N313	Uncharacterized protein.	Uncharacterized protein.	0.527
BN1708_010146	BN1708_012334	A0A0G4NC36	A0A0G4L900	Uncharacterized protein.	Uncharacterized protein.	0.433
BN1708_010352	BN1708_008315	A0A0G4KRR3	A0A0G4N313	RING-type domain-containing protein.	Uncharacterized protein.	0.466
BN1708_011920	BN1708_008315	A0A0G4L4X8	A0A0G4N313	MHD domain-containing protein; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.452
BN1708_012334	BN1708_008315	A0A0G4L900	A0A0G4N313	Uncharacterized protein.	Uncharacterized protein.	0.531
BN1708_012334	BN1708_010146	A0A0G4L900	A0A0G4NC36	Uncharacterized protein.	Uncharacterized protein.	0.433
BN1708_014076	BN1708_008315	A0A0G4LS80	A0A0G4N313	USP domain-containing protein; Belongs to the peptidase C19 family.	Uncharacterized protein.	0.485

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

10

PPI enrichment p-value:

0.219

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051536

Iron-sulfur cluster binding

7 of 146

1.1

1.06

0.00017

GO:0018492

Carbon-monoxide dehydrogenase (acceptor) activity

2 of 3

2.24

0.92

0.0200

GO:0016491

Oxidoreductase activity

7 of 239

0.89

0.71

0.0015

GO:0046872

Metal ion binding

7 of 405

0.66

0.41

0.0273

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4820

Mixed, incl. Alpha-helical ferredoxin, and Potassium ion transport

10 of 13

2.3

7.81

7.59e-19

CL:4823

Alpha-helical ferredoxin, and Lactate oxidation

5 of 5

2.42

4.03

1.16e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

nth00680

Methane metabolism

5 of 21

1.8

2.48

1.57e-06

nth01200

Carbon metabolism

5 of 89

1.17

1.05

0.00058

nth01120

Microbial metabolism in diverse environments

5 of 138

0.98

0.75

0.0030

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10418

Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B

2 of 2

2.42

0.79

0.0357

PF00175

Oxidoreductase NAD-binding domain

2 of 2

2.42

0.79

0.0357

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR009051

Alpha-helical ferredoxin

3 of 3

2.42

1.62

0.00096

IPR017900

4Fe-4S ferredoxin, iron-sulphur binding, conserved site

5 of 49

1.43

1.23

0.00096

IPR039261

Ferredoxin-NADP reductase (FNR), nucleotide-binding domain

2 of 2

2.42

0.89

0.0236

IPR037117

Dihydroorotate dehydrogenase, electron transfer subunit, Fe-S binding domain superfamily

2 of 2

2.42

0.89

0.0236

IPR019480

Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain

2 of 2

2.42

0.89

0.0236

(more ...)

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