MMYC01_208582 protein (Madurella mycetomatis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

MMYC01_208582

Uncharacterized protein. (232 aa)

Predicted Functional Partners:

MMYC01_209284

0.551

MMYC01_203161

0.551

MMYC01_204269

0.485

MMYC01_209211

0.479

MMYC01_208096

0.465

MMYC01_203328

0.465

MMYC01_210583

0.449

MMYC01_207520

0.406

MMYC01_206709

0.406

Your Current Organism:

Madurella mycetomatis

NCBI taxonomy Id: 100816
Other names: M. mycetomatis, Madurella ikedae, Madurella mycetomi, Streptotrix mycetomatis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MMYC01_203161	MMYC01_208582	A0A175W348	A0A175W1A6	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.551
MMYC01_203328	MMYC01_204269	A0A175W8E9	A0A175W397	DNA repair protein rhp26.	Transcription elongation factor S-II.	0.786
MMYC01_203328	MMYC01_208582	A0A175W8E9	A0A175W1A6	DNA repair protein rhp26.	Uncharacterized protein.	0.465
MMYC01_204269	MMYC01_203328	A0A175W397	A0A175W8E9	Transcription elongation factor S-II.	DNA repair protein rhp26.	0.786
MMYC01_204269	MMYC01_206709	A0A175W397	A0A175W284	Transcription elongation factor S-II.	Regulatory protein AfsR.	0.430
MMYC01_204269	MMYC01_208096	A0A175W397	A0A175VZP0	Transcription elongation factor S-II.	Switch 2.	0.786
MMYC01_204269	MMYC01_208582	A0A175W397	A0A175W1A6	Transcription elongation factor S-II.	Uncharacterized protein.	0.485
MMYC01_204269	MMYC01_209211	A0A175W397	A0A175VS93	Transcription elongation factor S-II.	Uncharacterized protein.	0.493
MMYC01_204269	MMYC01_210583	A0A175W397	A0A175VPG6	Transcription elongation factor S-II.	Uncharacterized protein.	0.428
MMYC01_206709	MMYC01_204269	A0A175W284	A0A175W397	Regulatory protein AfsR.	Transcription elongation factor S-II.	0.430
MMYC01_206709	MMYC01_208582	A0A175W284	A0A175W1A6	Regulatory protein AfsR.	Uncharacterized protein.	0.406
MMYC01_206709	MMYC01_209211	A0A175W284	A0A175VS93	Regulatory protein AfsR.	Uncharacterized protein.	0.906
MMYC01_207520	MMYC01_208582	A0A175W1P6	A0A175W1A6	Uncharacterized protein.	Uncharacterized protein.	0.406
MMYC01_207520	MMYC01_210583	A0A175W1P6	A0A175VPG6	Uncharacterized protein.	Uncharacterized protein.	0.513
MMYC01_208096	MMYC01_204269	A0A175VZP0	A0A175W397	Switch 2.	Transcription elongation factor S-II.	0.786
MMYC01_208096	MMYC01_208582	A0A175VZP0	A0A175W1A6	Switch 2.	Uncharacterized protein.	0.465
MMYC01_208582	MMYC01_203161	A0A175W1A6	A0A175W348	Uncharacterized protein.	SUMO-conjugating enzyme ubc9; Belongs to the ubiquitin-conjugating enzyme family.	0.551
MMYC01_208582	MMYC01_203328	A0A175W1A6	A0A175W8E9	Uncharacterized protein.	DNA repair protein rhp26.	0.465
MMYC01_208582	MMYC01_204269	A0A175W1A6	A0A175W397	Uncharacterized protein.	Transcription elongation factor S-II.	0.485
MMYC01_208582	MMYC01_206709	A0A175W1A6	A0A175W284	Uncharacterized protein.	Regulatory protein AfsR.	0.406

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140647

P450-containing electron transport chain

2 of 2

2.93

0.87

0.0273

GO:0006631

Fatty acid metabolic process

4 of 135

1.4

0.72

0.0273

GO:0006633

Fatty acid biosynthetic process

3 of 55

1.66

0.69

0.0439

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

3 of 24

2.02

1.17

0.0056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4546

Mixed, incl. Valine, leucine and isoleucine degradation, and Fatty acid metabolic process

6 of 118

1.63

2.14

3.72e-06

CL:4547

Mixed, incl. Valine, leucine and isoleucine degradation, and TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

5 of 109

1.59

1.88

1.88e-05

CL:4738

Mixed, incl. Thioesterase domain, and Quinone oxidoreductase/zeta-crystallin, conserved site

2 of 5

2.53

1.3

0.0041

CL:12660

Protein import into peroxisome matrix, and acyl-CoA binding

2 of 6

2.45

1.25

0.0050

CL:4676

Mixed, incl. Biotin-binding site, and Fatty acid metabolism

2 of 8

2.32

1.15

0.0074

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

4 of 33

2.01

2.39

1.08e-05

map00780

Biotin metabolism

3 of 18

2.15

1.99

0.00013

map01212

Fatty acid metabolism

4 of 127

1.42

1.29

0.00060

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.75

1.06

0.0119

MAP-9033241

Peroxisomal protein import

4 of 188

1.25

0.69

0.0244

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