STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (481 aa)    
Predicted Functional Partners:
MMYC01_201024
DNA-directed RNA polymerase II subunit rpb4.
 
  
   0.890
MMYC01_206984
Dehydrodolichyl diphosphate syntase complex subunit NUS1.
 
      0.853
MMYC01_206102
Alpha-1,2-galactosyltransferase.
 
      0.851
MMYC01_206877
Calcium-binding mitochondrial carrier protein; Belongs to the mitochondrial carrier (TC 2.A.29) family.
 
      0.709
MMYC01_206080
Deoxyuridine 5'-triphosphate nucleotidohydrolase.
    
  0.614
MMYC01_201462
Histone acetyltransferase type B subunit 2.
    
 0.605
MMYC01_202965
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
    
 0.595
MMYC01_201052
FAD synthase.
 
      0.584
MMYC01_207496
Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.
 
      0.575
MMYC01_205912
Replication factor A protein 2.
    
  0.572
Your Current Organism:
Madurella mycetomatis
NCBI taxonomy Id: 100816
Other names: M. mycetomatis, Madurella ikedae, Madurella mycetomi, Streptotrix mycetomatis
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