MMYC01_202525 protein (Madurella mycetomatis)

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Predicted Interactions

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MMYC01_202525

Apoptosis-inducing factor A. (398 aa)

Predicted Functional Partners:

MMYC01_204248

0.906

MMYC01_200978

0.906

MMYC01_204151

0.689

MMYC01_206650

0.689

MMYC01_201293

0.634

MMYC01_201999

0.574

MMYC01_205688

0.569

MMYC01_205731

0.563

MMYC01_202659

0.563

MMYC01_205012

0.556

Your Current Organism:

Madurella mycetomatis

NCBI taxonomy Id: 100816
Other names: M. mycetomatis, Madurella ikedae, Madurella mycetomi, Streptotrix mycetomatis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MMYC01_200978	MMYC01_201293	A0A175WFA5	A0A175WEY8	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.413
MMYC01_200978	MMYC01_201999	A0A175WFA5	A0A175WHE1	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.559
MMYC01_200978	MMYC01_202525	A0A175WFA5	A0A175W861	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Apoptosis-inducing factor A.	0.906
MMYC01_200978	MMYC01_204151	A0A175WFA5	A0A175VSI6	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein YmaE.	0.947
MMYC01_200978	MMYC01_204248	A0A175WFA5	A0A175W9J4	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Nitrate reductase [NADH].	0.960
MMYC01_200978	MMYC01_205012	A0A175WFA5	A0A175W129	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Thioredoxin reductase.	0.511
MMYC01_200978	MMYC01_205688	A0A175WFA5	A0A175W523	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Sulfite reductase [NADPH] subunit beta.	0.924
MMYC01_200978	MMYC01_206650	A0A175WFA5	A0A175VZ35	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Adrenodoxin, mitochondrial.	0.947
MMYC01_201293	MMYC01_200978	A0A175WEY8	A0A175WFA5	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.413
MMYC01_201293	MMYC01_201999	A0A175WEY8	A0A175WHE1	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	0.725
MMYC01_201293	MMYC01_202525	A0A175WEY8	A0A175W861	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Apoptosis-inducing factor A.	0.634
MMYC01_201293	MMYC01_202659	A0A175WEY8	A0A175WE49	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.972
MMYC01_201293	MMYC01_204248	A0A175WEY8	A0A175W9J4	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Nitrate reductase [NADH].	0.413
MMYC01_201293	MMYC01_205012	A0A175WEY8	A0A175W129	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Thioredoxin reductase.	0.857
MMYC01_201293	MMYC01_205731	A0A175WEY8	A0A175W0X3	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.972
MMYC01_201999	MMYC01_200978	A0A175WHE1	A0A175WFA5	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.559
MMYC01_201999	MMYC01_201293	A0A175WHE1	A0A175WEY8	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.725
MMYC01_201999	MMYC01_202525	A0A175WHE1	A0A175W861	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Apoptosis-inducing factor A.	0.574
MMYC01_201999	MMYC01_202659	A0A175WHE1	A0A175WE49	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.619
MMYC01_201999	MMYC01_204248	A0A175WHE1	A0A175W9J4	Glutathione reductase; Maintains high levels of reduced glutathione in the cytosol. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.	Nitrate reductase [NADH].	0.559

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Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.84

expected number of edges:

11

PPI enrichment p-value:

0.00172

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

6 of 221

1.47

1.6

6.34e-05

GO:0140647

P450-containing electron transport chain

2 of 2

3.04

1.32

0.0041

GO:0022900

Electron transport chain

3 of 61

1.73

0.93

0.0137

GO:0006633

Fatty acid biosynthetic process

3 of 70

1.67

0.89

0.0164

GO:0045454

Cell redox homeostasis

2 of 14

2.2

0.85

0.0272

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004165

delta(3)-delta(2)-enoyl-CoA isomerase activity

2 of 4

2.74

1.06

0.0121

GO:0004148

Dihydrolipoyl dehydrogenase activity

2 of 3

2.86

1.06

0.0121

GO:0000062

fatty-acyl-CoA binding

2 of 8

2.44

0.95

0.0181

GO:0016491

Oxidoreductase activity

7 of 1709

0.65

0.38

0.0449

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045252

Oxoglutarate dehydrogenase complex

2 of 7

2.5

1.06

0.0115

GO:0005739

Mitochondrion

8 of 1098

0.9

0.78

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10559

Beta-ketoacyl synthase, C-terminal domain, and Lipoate metabolic process

2 of 5

2.64

0.82

0.0329

CL:11194

Mixed, incl. Regulation of intracellular lipid transport, and Protein import into peroxisome matrix

2 of 12

2.26

0.78

0.0365

CL:13747

Mixed, incl. Sulfide oxidation to sulfate, and Sulfate assimilation

2 of 27

1.91

0.76

0.0370

CL:11090

Fatty acid beta-oxidation, and Acyl-CoA dehydrogenase, N-terminal domain

3 of 71

1.67

0.73

0.0365

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

3 of 137

1.38

0.69

0.0328

map00071

Fatty acid degradation

3 of 133

1.39

0.69

0.0328

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.86

1.36

0.0035

MAP-6783984

Glycine degradation

2 of 6

2.56

1.32

0.0039

MAP-389661

Glyoxylate metabolism and glycine degradation

3 of 53

1.79

1.21

0.0035

MAP-1362409

Mitochondrial iron-sulfur cluster biogenesis

2 of 16

2.14

0.97

0.0152

MAP-8978868

Fatty acid metabolism

5 of 345

1.2

0.91

0.0035

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005967

Mitochondrial pyruvate dehydrogenase complex

2 of 5

2.64

1.07

0.0112

GOCC:0005759

Mitochondrial matrix

4 of 165

1.43

0.88

0.0112

GOCC:0005739

Mitochondrion

6 of 857

0.89

0.57

0.0146

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0275

Fatty acid biosynthesis

3 of 9

2.56

2.43

2.99e-05

KW-0520

NAD

2 of 46

1.68

0.71

0.0404

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16113

Enoyl-CoA hydratase/isomerase

3 of 21

2.2

1.54

0.0012

PF02852

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.22

0.0060

PF00070

Pyridine nucleotide-disulphide oxidoreductase

2 of 10

2.34

0.96

0.0175

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001753

Enoyl-CoA hydratase/isomerase

3 of 22

2.18

1.29

0.0037

IPR029045

ClpP/crotonase-like domain superfamily

3 of 34

1.99

1.15

0.0062

IPR016156

FAD/NAD-linked reductase, dimerisation domain superfamily

2 of 5

2.64

1.08

0.0110

IPR004099

Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain

2 of 4

2.74

1.08

0.0110

IPR001100

Pyridine nucleotide-disulphide oxidoreductase, class I

2 of 4

2.74

1.08

0.0110

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