MMYC01_201232 protein (Madurella mycetomatis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

MMYC01_201232

Uncharacterized protein. (895 aa)

Predicted Functional Partners:

MMYC01_200743

0.835

MMYC01_204248

0.825

MMYC01_200978

0.825

MMYC01_205404

0.618

MMYC01_210313

0.516

MMYC01_202936

0.512

MMYC01_200205

0.510

MMYC01_202915

0.501

MMYC01_202903

0.497

MMYC01_209745

0.494

Your Current Organism:

Madurella mycetomatis

NCBI taxonomy Id: 100816
Other names: M. mycetomatis, Madurella ikedae, Madurella mycetomi, Streptotrix mycetomatis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MMYC01_200205	MMYC01_201232	A0A175WJQ6	A0A175WG55	U3 small nucleolar RNA-associated protein 5.	Uncharacterized protein.	0.510
MMYC01_200205	MMYC01_202903	A0A175WJQ6	A0A175WA41	U3 small nucleolar RNA-associated protein 5.	NET1-associated nuclear protein 1.	0.999
MMYC01_200205	MMYC01_202915	A0A175WJQ6	A0A175WB16	U3 small nucleolar RNA-associated protein 5.	U3 small nucleolar RNA-associated protein 4.	0.999
MMYC01_200205	MMYC01_202936	A0A175WJQ6	A0A175WAN1	U3 small nucleolar RNA-associated protein 5.	Small subunit processome component 20.	0.990
MMYC01_200205	MMYC01_209745	A0A175WJQ6	A0A175VS98	U3 small nucleolar RNA-associated protein 5.	Nucleolar complex protein 4.	0.997
MMYC01_200205	MMYC01_210313	A0A175WJQ6	A0A175VP80	U3 small nucleolar RNA-associated protein 5.	Nucleolar protein 58.	0.999
MMYC01_200743	MMYC01_200978	A0A175WI66	A0A175WFA5	Glycerophosphodiester phosphodiesterase GDE1.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.408
MMYC01_200743	MMYC01_201232	A0A175WI66	A0A175WG55	Glycerophosphodiester phosphodiesterase GDE1.	Uncharacterized protein.	0.835
MMYC01_200743	MMYC01_204248	A0A175WI66	A0A175W9J4	Glycerophosphodiester phosphodiesterase GDE1.	Nitrate reductase [NADH].	0.408
MMYC01_200743	MMYC01_205404	A0A175WI66	A0A175W1Y7	Glycerophosphodiester phosphodiesterase GDE1.	Ankyrin repeat protein nuc-2.	0.939
MMYC01_200978	MMYC01_200743	A0A175WFA5	A0A175WI66	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Glycerophosphodiester phosphodiesterase GDE1.	0.408
MMYC01_200978	MMYC01_201232	A0A175WFA5	A0A175WG55	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Uncharacterized protein.	0.825
MMYC01_200978	MMYC01_204248	A0A175WFA5	A0A175W9J4	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	Nitrate reductase [NADH].	0.960
MMYC01_201232	MMYC01_200205	A0A175WG55	A0A175WJQ6	Uncharacterized protein.	U3 small nucleolar RNA-associated protein 5.	0.510
MMYC01_201232	MMYC01_200743	A0A175WG55	A0A175WI66	Uncharacterized protein.	Glycerophosphodiester phosphodiesterase GDE1.	0.835
MMYC01_201232	MMYC01_200978	A0A175WG55	A0A175WFA5	Uncharacterized protein.	Nitrate reductase; Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.	0.825
MMYC01_201232	MMYC01_202903	A0A175WG55	A0A175WA41	Uncharacterized protein.	NET1-associated nuclear protein 1.	0.497
MMYC01_201232	MMYC01_202915	A0A175WG55	A0A175WB16	Uncharacterized protein.	U3 small nucleolar RNA-associated protein 4.	0.501
MMYC01_201232	MMYC01_202936	A0A175WG55	A0A175WAN1	Uncharacterized protein.	Small subunit processome component 20.	0.512
MMYC01_201232	MMYC01_204248	A0A175WG55	A0A175W9J4	Uncharacterized protein.	Nitrate reductase [NADH].	0.825

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.793

expected number of edges:

21

PPI enrichment p-value:

0.321

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 4

2.52

2.84

4.28e-06

GO:0016310

Phosphorylation

5 of 126

1.12

0.83

0.0042

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

6 of 171

1.06

0.81

0.0035

GO:0016775

Phosphotransferase activity, nitrogenous group as acceptor

3 of 31

1.5

0.79

0.0222

GO:0016773

Phosphotransferase activity, alcohol group as acceptor

4 of 75

1.25

0.76

0.0153

GO:0016301

Kinase activity

4 of 108

1.09

0.58

0.0361

GO:0016740

Transferase activity

8 of 566

0.67

0.45

0.0147

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3170

Mixed, incl. Import across plasma membrane, and Lipopolysaccharide transport

9 of 12

2.39

7.5

4.48e-17

CL:3172

Import across plasma membrane, and Regulation of catabolic process

5 of 5

2.52

4.24

6.21e-09

CL:2875

Mixed, incl. Signaling, and Cilium

10 of 163

1.31

2.11

2.06e-10

CL:3184

Lipopolysaccharide transport, and Ribonuclease H superfamily

2 of 5

2.12

0.77

0.0371

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsu02060

Phosphotransferase system (PTS)

4 of 4

2.52

3.39

3.48e-07

rsu00051

Fructose and mannose metabolism

2 of 12

1.74

0.71

0.0411

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0418

Kinase

4 of 99

1.13

0.58

0.0409

KW-0808

Transferase

7 of 508

0.66

0.39

0.0409

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